5 - TMR - YIYGSFK (a SRC tyrosine kinases substrate)

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Synonyms: [YIYGSFK], 5 - TMR labeled

Functional Activity:

Kinetic studies showed that the Km of YIYGSFK for p60c-src was 55 μM. It is about 6.4-fold lower than a peptide derived from p34cdc2 [cdc2(6-20), KVEKIGEGTYGVVYK] and has been reported to be a specific and efficient substrate for the Src-family protein tyrosine kinases. Comparison of the specificity of YIYGSFK and cdc2 (6-20) as a substrate for various Src-family and non-Src-family protein tyrosine kinases suggests that YIYGSFK is a much more specific and efficient substrate for the Src-family protein tyrosine kinases.

Technical Data:

M.Wt: 1289.5

Sequence (one-letter code): 5 - TMR - YIYGSFK

Sequence (three-letter code): 5 - TMR - Tyr - Ile - Tyr - Gly - Ser - Phe - Lys - OH

Excitation (nm): 547

Emission (nm): 573

Solubility: Soluble in DMSO

Purity: >95% (HPLC)

Shipping Conditions: Room temperature

Storage: Store and desiccate at -20°C and protect from light.

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References for 5 - TMR - YIYGSFK :

1. Lam, KS. et al. Int. J. Pept. Protein Res. 45, 587 (1995).

2. Hunter, T. Harvey Lect. 94, 81 (1998).

Certificate of Analysis/MSDS is available upon request

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