A549 cells
Catalog #:
C0016002
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Disease:
Lung carcinoma
The cells can synthesise lecithin utilising the cytidine diphosphocholine pathway
Homo sapiens
Lung
Epithelial
Adherent
This is a hypotriploid human cell line
Male, Caucasian, 58 yrs of age
F-12K Nutrient Mixture (Kaighn's Modification) + 10% FBS
1:3 to 1:8 using 0.25% trypsin or trypsin/EDTA, 5% CO2; 37°C
Complete culture medium supplemented with 5% (v/v) DMSO
Bacteria: Negative
Yeast: Negative
Mycoplasma: Negative
HIV: Negative
Hepatitis B: Negative
Hepatitis C: Negative
If use of this culture results in a scientific publication, it should be cited in the publication as: A549 (AddexBio C0016002)
Origin:
Species:
Tissue:
Morphology:
Properties:
Cytogenic data:
Patient:
Medium:
Subculture:
Freezing Medium:
Biosafety Level:
I
Sterility:
Pathogens:
Protein Expression:
Isoenzymes:
G6PD, B
DNA Profile (STR):
Amelogenin: X,Y
CSF1PO: 10,12
D13S317: 11
D16S539: 11,12
D5S818: 11
D7S820: 8,11
THO1: 8,9.3
TPOX: 8,11
vWA: 14
Related cells by Organ:
References for A549 cells:
1. Armstrong, D. A., Phelps, L. N., and Vincenti, M. P. CCAAT enhancer binding protein-beta regulates matrix metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung carcinoma cells. Mol Cancer Res, 7: 1517-1524, 2009.
2. Tomankova, K., Kolarova, H., Bajgar, R., Jirova, D., Kejlova, K., and Mosinger, J. Study of the photodynamic effect on the A549 cell line by atomic force microscopy and the influence of green tea extract on the production of reactive oxygen species. Ann N Y Acad Sci, 1171: 549-558, 2009.
3. Chuang, C. Y., Chen, T. L., and Chen, R. M. Molecular mechanisms of lipopolysaccharide-caused induction of surfactant protein-A gene expression in human alveolar epithelial A549 cells. Toxicol Lett, 191: 132-139, 2009.
4. Wei, C. W., Lin, C. C., Yu, Y. L., Lin, C. Y., Lin, P. C., Wu, M. T., Chen, C. J., Chang, W., Lin, S. Z., Chen, Y. L., and Harn, H. J. n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2alpha and telomerase activity. Acta Pharmacol Sin, 30: 1297-1306, 2009.
5. Su, J. C., Lin, K. L., Chien, C. M., Lu, C. M., Chen, Y. L., Chang, L. S., and Lin, S. R. Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation. Life Sci, 85: 505-516, 2009.
6. Ding, X. L., Zhang, H. Y., Qi, L., Zhao, B. X., Lian, S., Lv, H. S., and Miao, J. Y. Synthesis of novel pyrazole carboxamide derivatives and discovery of modulators for apoptosis or autophagy in A549 lung cancer cells. Bioorg Med Chem Lett, 19: 5325-5328, 2009.
