MOLM-13 cells
Catalog #:
C0003003
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| Frozen vial | USD450.0 |
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Disease:
Acute myeloid leukemia (AML)
Established from the peripheral blood
Homo sapiens
Blood
Suspension
Hyperdiploid karyotype
Male, 20 yrs of age
AddexBio-formulated RPMI-1640 Medium (C0004-01)
+ 20% FBS
Cultures can be maintained by the addition or replacement of fresh medium. Start new cultures at 1 X 105 viable cells/ml. Subculture at 1 X 106 cells/ml. Culture cells at 5% CO2, 37°C.
Split saturated culture 1:2 to 1:3.
Complete culture medium supplemented with 5% (v/v) DMSO
I
Bacteria: Negative
Yeast: Negative
Mycoplasma: Negative
HIV: Negative
Hepatitis B: Negative
Hepatitis C: Negative
Origin:
Species:
Tissue:
Properties:
Cytogenic data:
Patient:
Medium:
Subculture:
Medium Renewal:
Freezing Medium:
Biosafety Level:
Sterility:
Pathogens:
DNA Profile (STR):
Amelogenin: X,Y;
CSF1PO: 10;
D13S317: 10,11;
D16S539: 10,11;
D5S818: 10,11;
D7S820: 10,12;
THO1: 7;
TPOX: 8;
vWA: 16,17
Protein Expression:
CD3 -, CD4 +, CD13 (+), CD14 -, CD15 +, CD19 -, CD33 +, CD34 -, cyCD68 +, HLA-DR -
Related cells by Organ:
CCRF-CEM
References for MOLM-13 cells:
1. Fang J et al. Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-?B gene network. Cell Rep. 2014;8(5):1328-1338. PMID:25199827
2. Qi W, Zhang W, Edwards H, Chu R, Madlambayan GJ, Taub JW, Wang Z, Wang Y, Li C, Lin H, Ge Y. Synergistic anti-leukemic interactions between panobinostat and MK-1775 in acute myeloid leukemia ex vivo. Cancer Biol Ther. 2015;16(12):1784-1793. doi: 10.1080/15384047.2015.1095406. PMID:26529495
3. Montemurro, L., Tonelli, R., Fazzina, R., Martino, V., Marino, F., and Pession, A. Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line. Cancer Genet Cytogenet, 154: 96-97, 2004.
4. Qi W, Xie C, Li C, Caldwell JT, Edwards H, Taub JW, Wang Y1, Lin H, Ge Y. CHK1 plays a critical role in the anti-leukemic activity of the wee1 inhibitor MK-1775 in acute myeloid leukemia cells. J Hematol Oncol. 2014 Aug 1;7:53. PMID: 25084614
5. Luedtke DA, Niu X, Pan Y, Zhao J, Liu S, Edwards H, Chen K, Lin H, Taub JW, Ge Y. Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells. Signal Transduct Target Ther. 2017 Apr 7;2:17012. doi: 10.1038/sigtrans.2017.12. PMID: 29263915
