4T1 cells
Catalog #:
C0006004
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| Frozen vial | USD420.0 |
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Disease:
Breast Cancer
4T1 is a 6-thioguanine resistant cell line selected from the 410.4 tumor without mutagen treatment
Mus musculus (mouse)
Breast, mammary gland
Epithelial
Adherent
When injected into BALB/c mice, 4T1 spontaneously produces highly metastatic tumors that can metastasize to the lung, liver, lymph nodes and brain while the primary tumor is growing in situ
BALBcfC3H
AddexBio-formulated RPMI-1640 Medium(C0004-01) + 10% FBS
1:6 to 1:8 using 0.25% trypsin or trypsin/EDTA, 5% CO2; 37°C
Complete culture medium supplemented with 5% (v/v) DMSO
I
Bacteria: Negative
Yeast: Negative
Mycoplasma: Negative
HIV: Negative
Hepatitis B: Negative
Hepatitis C: Negative
If use of this culture results in a scientific publication, it should be cited in the publication as: 4T1 (AddexBio C0006004)
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References for 4T1 cells:
1. Baliga MS, Meleth S, and Katiyar SK. Growth inhibitory and antimetastatic effect of green tea polyphenols on metastasis-specific mouse mammary carcinoma 4T1 cells in vitro and in vivo systems. Clin Cancer Res 11: 1918-1927, 2005.
2. Bove K, Lincoln DW, and Tsan MF. Effect of resveratrol on growth of 4T1 breast cancer cells in vitro and in vivo. Biochem Biophys Res Commun 291: 1001-1005, 2002.
3. Chen L, Huang TG, Meseck M, Mandeli J, Fallon J, and Woo SL. Rejection of metastatic 4T1 breast cancer by attenuation of Treg cells in combination with immune stimulation. Mol Ther 15: 2194-2202, 2007.
4. De S, Miller DW, and Robinson DH. Effect of particle size of nanospheres and microspheres on the cellular-association and cytotoxicity of paclitaxel in 4T1 cells. Pharm Res 22: 766-775, 2005.
5. Hong X, Liu Y, Hu G, Zhao D, Shen J, Shen F, Cao X, and Wang Q. EBAG9 inducing hyporesponsiveness of T cells promotes tumor growth and metastasis in 4T1 murine mammary carcinoma. Cancer Sci 100: 961-969, 2009.
6. Israyelyan A, Shannon EJ, Baghian A, Kearney MT, and Kousoulas KG. Thalidomide suppressed the growth of 4T1 cells into solid tumors in Balb/c mice in a combination therapy with the oncolytic fusogenic HSV-1 OncdSyn. Cancer Chemother Pharmacol 64: 1201-1210, 2009.
7. Jun JY, Griffith JW, Bruggeman R, Washington S, Demers LM, Verderame MF, and Manni A. Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. Breast Cancer Res Treat 105: 29-36, 2007.
8. Jun JY, Griffith JW, Bruggeman R, Washington S, Demers LM, Verderame MF, and Manni A. Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. Breast Cancer Res Treat 107: 33-40, 2008.
9. Le HK, Graham L, Cha E, Morales JK, Manjili MH, and Bear HD. Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice. Int Immunopharmacol 9: 900-909, 2009.
10. Rachid M, Matar C, Duarte J, and Perdigon G. Effect of milk fermented with a Lactobacillus helveticus R389(+) proteolytic strain on the immune system and on the growth of 4T1 breast cancer cells in mice. FEMS Immunol Med Microbiol 47: 242-253, 2006.
