Fluorescein-5-maleimide

Catalog #:

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Synonyms: 1H-Pyrrole-2,5-dione, 1-(3',6'-dihydroxy-3-oxospiro(isobenzofuran-1(3H),9'-(9H)xanthen-5-yl)-

Functional Activity:

Fluorescein-5-maleimide is one of the most popular fluorescent dyes for thiol modifications of proteins along with 5-TMRIA. Maleimides are among the most frequently used reagents for thiol modification. In most proteins, the site of reaction is at cysteine residues that either are intrinsically present or result from reduction of cystines. Unlike iodoacetamides, maleimides do not react with histidines and methionines under physiological conditions.

Technical Data:

M.Wt: 427.36

Formula: C₂₄H₁₃NO₇

Excitation (nm): 493

Emission (nm): 515

Solubility: Soluble in DMSO, DMF

Purity: >95% (HPLC)

Shipping Conditions: Room temperature

Storage: Store and desiccate at -20°C and protect from light.

CAS No.: 75350-46-8

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References for Fluorescein-5-maleimide :

1 Winograd E, et al. (2004). Chemical modifications of band 3 protein affect the adhesion of Plasmodium falciparum-infected erythrocytes to CD36. Mol Biochem Parasitol 136, 243-8;

2. van der Sluis EO, et al. (2002). SecY-SecY and SecY-SecG contacts revealed by site-specific crosslinking. FEBS Lett 527, 159-65.

Certificate of Analysis/MSDS is available upon request