L-Canavanine sulfate
Catalog #:
IN0107| IN0107-10mg | USD29.0 |
Synonyms: L-Canavanine sulfate , L-α-Amino-γ-(guanidinooxy)butyric acid sulfate salt, L-canavanine, canavanine, GGB, L(+)-Canavanine
IUPAC Name:
(2S)-2-amino-4-(diaminomethylideneamino)oxybutanoic acid
Functional Activity:
Naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS).
Technical Data:
M.Wt: 274.25
Formula: C5H12N4O3.H2SO4
Solubility: Soluble to 100 mg/mL in water
Purity: >99%
Storage: Dessicate at 4°C
CAS No.: 2219-31-0
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References for L-Canavanine sulfate:
1. Vynnytska-Myronovska, B., Bobak, Y., Garbe, Y., Dittfeld, C., Stasyk, O., and Kunz-Schughart, L. A. Single amino acid arginine starvation efficiently sensitizes cancer cells to canavanine treatment and irradiation. Int J Cancer.
2. Vynnytska, B. O., Mayevska, O. M., Kurlishchuk, Y. V., Bobak, Y. P., and Stasyk, O. V. Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells. Anticancer Drugs, 22: 148-157.
3. Bence, A. K. and Crooks, P. A. The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery. J Enzyme Inhib Med Chem, 18: 383-394, 2003.
4. Bence, A. K., Adams, V. R., and Crooks, P. A. L-Canavanine as a radiosensitization agent for human pancreatic cancer cells. Mol Cell Biochem, 244: 37-43, 2003.
5. Miersch, J., Grancharov, K., Pajpanova, T., Tabakova, S., Stoev, S., Krauss, G. J., and Golovinsky, E. Synthesis and biological activity of canavanine hydrazide derivatives. Amino Acids, 18: 41-59, 2000.
6. Yang, W., Urano, J., and Tamanoi, F. Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe. J Biol Chem, 275: 429-438, 2000.
