Tetramethylrhodamine-5 maleimide

Catalog #:

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Synonyms: 5-TAMRA maleimide

Functional Activity:

Tetramethylrhodamine-5-maleimide is the purified single isomer of tetramethylrhodamine-5 (and 6)-maleimide mixed isomers, and is widely used for thiol modifications of peptides and proteins to yield photostable, pH-insensitive, red-orange?fluorescent conjugates. Maleimides are among the most frequently used reagents for thiol modification. In most proteins, the sites of reactions are at cysteine residues that either are intrinsically present or result from reduction of cystines. Unlike iodoacetamides, maleimides do not react with histidines and methionines under physiological conditions.

Technical Data:

M.Wt: 481.51

Formula: C₂₈H₂₃N₃O₅

Excitation (nm): 540

Emission (nm): 567

Solubility: Soluble in DMSO, DMF

Purity: >95% (HPLC)

Shipping Conditions: Room temperature

Storage: Store and desiccate at -20°C and protect from light.

CAS No.: 174568-67-3

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References for Tetramethylrhodamine-5 maleimide :

1. Graceffa P and Dominguez R (2003). Crystal structure of monomeric actin in the ATP state. Structural basis of nucleotide-dependent actin dynamics. J Biol Chem 278, 34172-80.

2. Tong Y, et al. (2001). Tyrosine decaging leads to substantial membrane trafficking during modulation of an inward rectifier potassium channel. J Gen Physiol 117, 103-18.

Certificate of Analysis/MSDS is available upon request