Amiloride hydrochloride
Catalog #:
IN0062Shipping advice:
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Synonyms: Amiloride hydrochloride, N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
IUPAC Name:
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamideFunctional Activity:
Amiloride is a selective T-type calcium channel blocker and blocker of epithelial Na+ channel. It is also a selective inhibitor of urokinase plasminogen activator (uPA). Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding sites. Amiloride is also known to inhibit TRPP3 channels. It is a nonselective inhibitor of Na+/H+ exchanger
Technical Data:
M.Wt: 266.09
Formula: C6H8ClN7O..HCl.xH2O
Solubility: Soluble in water at 50mg/mL
Purity: >98%
Storage: Dessicate at RT
CAS No.: 2016-88-8
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References for Amiloride hydrochloride :
1. Almaca, J., et al., Functional Genomics Assays To Study CFTR Traffic And ENaC Function. Methods Mol. Biol. 742, 249-64,2011
2 Tang, C.M., et al., Amiloride selectively blocks the low threshold (T) calcium channel. Science 240, 213-215,1988
3 Kleyman, T.R. and Kragoe, E.J., Jr., Amiloride and its analogs as tools in the study of ion transport. J. Membr. Biol. 105, 1-21,1988
4 Jankun, J., and Skrzypczak-Jankun, E., Molecular basis of specific inhibition of urokinase plasminogen activator by amiloride. Cancer Biochem. Biophys. 17, 109-123,1999
