CYP and UGT Phenotyping and Identification

CYP and UGT phenotyping, or identification, determines the CYP and/or UGT enzymes that are involved in the metabolism of a compound. AddexBio will use FDA-approved criteria in this study including specific chemical inhibition, and/or recombinant enzymes. We also perform correlation analysis that involves a donor bank of liver microsomes of at least 10 donors. Pilot studies will be conducted to determine the appropriate reaction conditions for each project.