Tetramethylrhodamine-5-(and-6)-maleimide

Catalog #:

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Synonyms: 5(6)-TAMRA maleimide

Functional Activity:

Tetramethylrhodamine-5-(and-6)-maleimide is an excellent reagent for preparing orange fluorescent bioconjugates through thiol modifications of peptides, nucleotides, nucleic acids and proteins. Maleimides are among the most frequently used reagents for thiol modification. In most proteins, the sites of reactions are at cysteine residues that either are intrinsically present or result from reduction of cystines. Unlike iodoacetamides, maleimides do not react with histidines and methionines under physiological conditions.

Technical Data:

M.Wt: 481.51

Formula: C₂₈H₂₃N₃O₅

Excitation (nm): 540

Emission (nm): 567

Solubility: Soluble in DMSO, DMF

Purity: >95% (HPLC)

Shipping Conditions: Room temperature

Storage: Store and desiccate at -20°C and protect from light.

CAS No.: N/A

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References for Tetramethylrhodamine-5-(and-6)-maleimide :

1. Geibel S, et al. (2003). Conformational dynamics of the Na+/K¬+-ATPase probed by voltage clamp fluorometry. Proc Natl Acad Sci USA 100, 964-9;

2. Cha A and Bezanilla F (1998). Structural implications of fluorescence quenching in the Shaker K+ channel. J Gen Physiol 112, 391-408.

Certificate of Analysis/MSDS is available upon request