Hg-Ag1.5
Catalog #:
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Synonyms: Hg-Agonist 1.5
IUPAC Name:
3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide
Functional Activity:
A potent agonist of the Hh pathway. Activation of Hh signaling via introduction of a Hh-protein ligand has shown therapeutic benefit in mice models of PD and peripheral nerve damage.
Technical Data:
M.Wt: 566.07
Formula: C29H28Cl F2N3O2S
Solubility: Soluble in DMSO
Purity: >98% (LCMS)
Storage: 2-8°C
CAS No.:
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References for Hg-Ag1.5 :
1. Tsuboi, K.; Shults, C. W. Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease. Exp. Neurol. 2002, 173, 95?104.
2. Pepinsky, R. B.; Shapiro, R. I.; Wang, S.; Chakraborty, A.; Gill, A.; Lepage, D. J.; Wen, D.; Rayhorn, P.; Horan, G. S. B.; Taylor, F. R.; Garber, E. A.; Galdes, A.; Engber, T. M. Long acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model. J. Pharm. Sci. 2002, 91, 371?387.
3. Frank-Kamenetsky, M.; Zhang, X. M.; Bottega, S.; Guicherit, O.; Wichterle, H.; Dudek, H.; Bumcrot, D.; Wang, F. Y.; Jones, S.; Shulok, J.; Rubin, L. L.; Porter, J. A. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J. Biol. 2002, 1, 10.