Hg-Ag1.5

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Synonyms: Hg-Agonist 1.5

IUPAC Name:

3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide

Functional Activity:

A potent agonist of the Hh pathway. Activation of Hh signaling via introduction of a Hh-protein ligand has shown therapeutic benefit in mice models of PD and peripheral nerve damage.

Technical Data:

M.Wt: 566.07

Formula: C₂₉H₂₈Cl F₂N₃O₂S

Solubility: Soluble in DMSO

Purity: >98% (LCMS)

Storage: 2-8°C

CAS No.:

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References for Hg-Ag1.5 :

1. Tsuboi, K.; Shults, C. W. Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease. Exp. Neurol. 2002, 173, 95?104.

2. Pepinsky, R. B.; Shapiro, R. I.; Wang, S.; Chakraborty, A.; Gill, A.; Lepage, D. J.; Wen, D.; Rayhorn, P.; Horan, G. S. B.; Taylor, F. R.; Garber, E. A.; Galdes, A.; Engber, T. M. Long acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model. J. Pharm. Sci. 2002, 91, 371?387.

3. Frank-Kamenetsky, M.; Zhang, X. M.; Bottega, S.; Guicherit, O.; Wichterle, H.; Dudek, H.; Bumcrot, D.; Wang, F. Y.; Jones, S.; Shulok, J.; Rubin, L. L.; Porter, J. A. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J. Biol. 2002, 1, 10.

Certificate of Analysis/MSDS is available upon request with lot number