Flavopiridol
Catalog #:
IN0129
| IN0129-5mg | USD50.0 |
Synonyms: Flavopiridol, Alvocidib, FLAVO, L-868275
IUPAC Name:
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S, 4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one
Functional Activity:
Flavopiridol is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. It has been studied also for the treatment of arthritis and atherosclerotic plaque formation.
Flavopiridol is a synthetic flavonoid based on an extract from an Indian plant for the potential treatment of non-small lung cancer. Technical Data:
M.Wt: 401.84
Formula: C21H20Cl NO5
Solubility: Soluble in DMSO
Purity: >99%
Storage: Store at -20°C
CAS No.: 146426-40-6
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References for Flavopiridol:
1. Rathkopf, D., Dickson, M. A., Feldman, D. R., Carvajal, R. D., Shah, M. A., Wu, N., Lefkowitz, R., Gonen, M., Cane, L. M., Dials, H. J., Winkelmann, J. L., Bosl, G. J., and Schwartz, G. K. Phase I study of flavopiridol with oxaliplatin and fluorouracil/leucovorin in advanced solid tumors. Clin Cancer Res, 15: 7405-7411, 2009.
2. Lin, T. S., Ruppert, A. S., Johnson, A. J., Fischer, B., Heerema, N. A., Andritsos, L. A., Blum, K. A., Flynn, J. M., Jones, J. A., Hu, W., Moran, M. E., Mitchell, S. M., Smith, L. L., Wagner, A. J., Raymond, C. A., Schaaf, L. J., Phelps, M. A., Villalona-Calero, M. A., Grever, M. R., and Byrd, J. C. Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. J Clin Oncol, 27: 6012-6018, 2009.
3. Christian, B. A., Grever, M. R., Byrd, J. C., and Lin, T. S. Flavopiridol in chronic lymphocytic leukemia: a concise review. Clin Lymphoma Myeloma, 9 Suppl 3: S179-185, 2009.
4. Ali, A., Ghosh, A., Nathans, R. S., Sharova, N., O'Brien, S., Cao, H., Stevenson, M., and Rana, T. M. Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication. Chembiochem, 10: 2072-2080, 2009.
5. Purcell, E. K., Thompson, D. E., Ludwig, K. A., and Kipke, D. R. Flavopiridol reduces the impedance of neural prostheses in vivo without affecting recording quality. J Neurosci Methods, 183: 149-157, 2009.
6. Bonvini, P., Zorzi, E., Mussolin, L., Monaco, G., Pigazzi, M., Basso, G., and Rosolen, A. The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity. Haematologica, 94: 944-955, 2009.
