δ-Hydroxylysine
Catalog #:
IN0126| IN0126-10mg | USD45.0 |
Synonyms: 2,6-Diamino-5-hydroxycaproic acid hydrochloride, 2,6-Diamino-5-hydroxyhexanoic acid hydrochloride, DL-5-Hydroxylysine hydrochloride
IUPAC Name:
(±)-2-(2-{4-[(4-chlorophenyl)-phenylmethyl]piperazin -1-yl}ethoxy)ethanol
Functional Activity:
Glutamine synthetase inhibitor. It is also an α-aminoadipate-semialdehyde dehydrogenase inhibitor (Ki of 1.65 mM) and Aspartate kinase regulator.
Technical Data:
M.Wt: 198.65
Formula: C6H15ClN2O3
Solubility: Soluble in DMSO and ethanol
Purity: >97%
Storage: Dessicate at 4°C
CAS No.: 13204-98-3
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References for δ-Hydroxylysine
1. Fricke, O., Land, C., Beccard, R., Semler, O., Stabrey, A., and Schoenau, E. The relationship between body composition and the urinary excretion of deoxypyridinoline and galactosyl-hydroxylysine in children and adolescents. J Bone Miner Metab, 27: 689-697, 2009.
2. Dittrich, B., McKinnon, J. J., and Warren, J. E. Improvement of anisotropic displacement parameters from invariom-model refinements for three L-hydroxylysine structures. Acta Crystallogr B, 64: 750-759, 2008.
3. Takaluoma, K., Hyry, M., Lantto, J., Sormunen, R., Bank, R. A., Kivirikko, K. I., Myllyharju, J., and Soininen, R. Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice. J Biol Chem, 282: 6588-6596, 2007.
4. Langrock, T., Garcia-Villar, N., and Hoffmann, R. Analysis of hydroxyproline isomers and hydroxylysine by reversed-phase HPLC and mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 847: 282-288, 2007.
5. Gustafsson, T., Hedenstrom, M., and Kihlberg, J. Synthesis of a C-glycoside analogue of beta-D-galactosyl hydroxylysine and incorporation in a glycopeptide from type II collagen. J Org Chem, 71: 1911-1919, 2006.
6. Marin, J., Blaton, M. A., Briand, J. P., Chiocchia, G., Fournier, C., and Guichard, G. Synthesis of glycopeptides from type II collagen-incorporating galactosylated hydroxylysine mimetics and their use in studying the fine specificity of arthritogenic T cells. Chembiochem, 6: 1796-1804, 2005.
