Pargyline hydrochloride
Catalog #:
IN0116| IN0116-10mg | USD29.0 |
Synonyms: N-Methyl-N-propargylbenzylamine hydrochloride
IUPAC Name:
N-Methyl-N-(2-propynyl)benzylamine hydrochloride
Functional Activity:
Selective and irreversible MAO-B inhibitor. It inhibits the metabolism of catecholamines and tyramine within presynaptic nerve terminals and therefore has antihypertensive effects.
Technical Data:
M.Wt: 195.69
Formula: C11H14ClN
Solubility: Soluble in water
Purity: >99%
Storage: Dessicate at -20°C
CAS No.: 306-07-0
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References for Pargyline hydrochloride
1. Upadhyay, A. K. and Edmondson, D. E. Development of spin-labeled pargyline analogues as specific inhibitors of human monoamine oxidases A and B. Biochemistry, 48: 3928-3935, 2009.
2. Buneeva, O. A., Medvedeva, M. V., and Medvedev, A. E. [Analysis of ubiquitin-dependent regulation of the monoamine oxidase sensitivity to proteolysis and specific inhibition by pargyline]. Biomed Khim, 54: 720-726, 2008.
3. Larsen, T. R., Rossen, S., and Gramsbergen, J. B. Dopamine release in organotypic cultures of foetal mouse mesencephalon: effects of depolarizing agents, pargyline, nomifensine, tetrodotoxin and calcium. Eur J Neurosci, 28: 569-576, 2008.
4. Lima, F. B., Szawka, R. E., Anselmo-Franci, J. A., and Franci, C. R. Pargyline effect on luteinizing hormone secretion throughout the rat estrous cycle: correlation with serotonin, catecholamines and nitric oxide in the medial preoptic area. Brain Res, 1142: 37-45, 2007.
5. Liao, P. C., Kuo, Y. M., Chang, Y. C., Lin, C., Cherng, C. F., and Yu, L. Striatal formation of 6-hydroxydopamine in mice treated with pargyline, pyrogallol and methamphetamine. J Neural Transm, 110: 487-494, 2003.
6. Panova, N. G., Axenova, L. N., and Medvedev, A. E. The effect of ethanol consumption on the sensitivity of rat brain monoamine oxidases to the inhibition by pargyline in vivo and in vitro. Neurobiology (Bp), 8: 225-230, 2000.
