Hemicholine
Catalog #:
IN0113Shipping advice:
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Synonyms:
IUPAC Name:
2,2'-(4,4'-Biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium bromide)
Functional Activity:
Potent and selective choline uptake inhibitor by blocking transporter ChT at the presynapse. It decreases the synthesis of acetylcholine since the reuptake of choline is the rate limiting step in the synthesis of acetylcholine. Therefore, it is classified as an indirect acetylcholine antagonist.
Technical Data:
M.Wt: 574.35
Formula: C24H34Br2 N2O4
Solubility: Soluble in ethanol
Purity: >95%
Storage: Dessicate at RT
CAS No.: 961-45-5
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References for Hemicholinium-3
1. Kristofikova, Z., Kopecky, V., Jr., Hofbauerova, K., Hovorkova, P., and Ripova, D. Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers. Neurochem Res, 33: 412-421, 2008.
2. Zheng, Q. H., Gao, M., Mock, B. H., Wang, S., Hara, T., Nazih, R., Miller, M. A., Receveur, T. J., Lopshire, J. C., Groh, W. J., Zipes, D. P., Hutchins, G. D., and DeGrado, T. R. Synthesis and biodistribution of new radiolabeled high-affinity choline transporter inhibitors [11C]hemicholinium-3 and [18F]hemicholinium-3. Bioorg Med Chem Lett, 17: 2220-2224, 2007.
3. Gao, M., Miller, M. A., DeGrado, T. R., Mock, B. H., Lopshire, J. C., Rosenberger, J. G., Dusa, C., Das, M. K., Groh, W. J., Zipes, D. P., Hutchins, G. D., and Zheng, Q. H. Evaluation of [11C]hemicholinium-15 and [18F]hemicholinium-15 as new potential PET tracers for the high-affinity choline uptake system in the heart. Bioorg Med Chem, 15: 1289-1297, 2007.
4. Boccia, M. M., Blake, M. G., Acosta, G. B., and Baratti, C. M. Post-retrieval effects of icv infusions of hemicholinium in mice are dependent on the age of the original memory. Learn Mem, 13: 376-381, 2006.
5. Mandl, P. and Kiss, J. P. Inhibitory effect of hemicholinium-3 on presynaptic nicotinic acetylcholine receptors located on the terminal region of myenteric motoneurons. Neurochem Int, 49: 327-333, 2006.
6. Ferguson, S. M., Bazalakova, M., Savchenko, V., Tapia, J. C., Wright, J., and Blakely, R. D. Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice. Proc Natl Acad Sci U S A, 101: 8762-8767, 2004.
