Probenecid
Catalog #:
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Synonyms: p-(Dipropylsulfamoyl)benzoic acid
IUPAC Name:
4-(Dipropylsulfamoyl)benzoic acid
Functional Activity:
Inhibitor of multidrug resistance-associated proteins (MRP), the organic anion transporters across the membrane of hepatocytes and renal tubule cells.
Technical Data:
M.Wt: 285.36
Formula: C13H19NO4S
Solubility: Soluble in DMSO and ethanol
Purity: >98%
Storage: Dessicate at RT
CAS No.: 57-66-9
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References for Probenecid
1. Vamos, E., Pardutz, A., Fejes, A., Tajti, J., Toldi, J., and Vecsei, L. Modulatory effects of probenecid on the nitroglycerin-induced changes in the rat caudal trigeminal nucleus. Eur J Pharmacol, 621: 33-37, 2009.
2. Raisch, D. W., Straight, T. M., and Holodniy, M. Thrombocytopenia from combination treatment with oseltamivir and probenecid: case report, MedWatch data summary, and review of the literature. Pharmacotherapy, 29: 988-992, 2009.
3. Vamos, E., Pardutz, A., Varga, H., Bohar, Z., Tajti, J., Fulop, F., Toldi, J., and Vecsei, L. l-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerin-induced nNOS in the rat caudal trigeminal nucleus. Neuropharmacology, 57: 425-429, 2009.
4. Landersdorfer, C. B., Kirkpatrick, C. M., Kinzig, M., Bulitta, J. B., Holzgrabe, U., Drusano, G. L., and Sorgel, F. Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid. Antimicrob Agents Chemother, 53: 3902-3907, 2009.
5. Vamos, E., Voros, K., Zadori, D., Vecsei, L., and Klivenyi, P. Neuroprotective effects of probenecid in a transgenic animal model of Huntington's disease. J Neural Transm, 116: 1079-1086, 2009.
6. Monien, B. H., Muller, C., Bakhiya, N., Donath, C., Frank, H., Seidel, A., and Glatt, H. Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats. Toxicology, 262: 80-85, 2009.