Indomethacin
Catalog #:
IN0109| IN0109-50mg | USD39.0 |
Synonyms:
IUPAC Name:
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole
Functional Activity:
Cyclooxgenase (COX) inhibitor that displays selectivity for COX-1 (IC50 230 nM)to inhibit the production of prostaglandins. It is commonly used as a non-steroidal anti-inflammatory drug to reduce fever, pain, stiffness, and swelling. .
Technical Data:
M.Wt: 357.79
Formula: C19H16ClNO4
Solubility: Soluble in DMSO and ethanol
Purity: >99%
Storage: Dessicate at RT
CAS No.: 53-86-1
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References for Indomethacin
1. Kim, K. R., Lee, J. Y., Kim, M. K., and Yoon, T. Y. Successful Treatment of Recalcitrant Primary Follicular Mucinosis with Indomethacin and Low-dose Intralesional Interferon Alpha. Ann Dermatol, 21: 285-287, 2009.
2. Mesnukul, A., Yodkhum, K., and Phaechamud, T. Solid Dispersion Matrix Tablet Comprising Indomethacin-PEG-HPMC Fabricated with Fusion and Mold Technique. Indian J Pharm Sci, 71: 413-420, 2009.
3. Harusato, A., Naito, Y., Takagi, T., Yamada, S., Mizushima, K., Hirai, Y., Horie, R., Inoue, K., Fukumoto, K., Hirata, I., Omatsu, T., Kishimoto, E., Uchiyama, K., Handa, O., Ishikawa, T., Kokura, S., Ichikawa, H., Muto, A., Igarashi, K., and Yoshikawa, T. Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice. J Physiol Pharmacol, 60 Suppl 7: 149-154, 2009.
4. Namazi, M. R. Potential utility of indomethacin in enhancing the leishmanicidal activity of glucantime. East Mediterr Health J, 15: 1624-1625, 2009.
5. Das Gupta, A. B., Hossain, A. K., Islam, M. H., Dey, S. R., and Khan, A. L. Role of omega-3 fatty acid supplementation with indomethacin in suppression of disease activity in rheumatoid arthritis. Bangladesh Med Res Counc Bull, 35: 63-68, 2009.
6. Liu, H. and Chen, J. Indomethacin-loaded poly(butylcyanoacrylate) nanoparticles: preparation and characterization. PDA J Pharm Sci Technol, 63: 207-216, 2009.
