2-Chloroadenosine
Catalog #:
AG0026| AG0026-20mg | USD45.0 |
Synonyms: 2-Chloroadenosine , Chloroadenosine, Cl-Ado, 2 ClAdo, 2-chloroadenosinehemihydrate, 2-CADO, 6-Amino-2-chloropurine riboside
IUPAC Name:
(2R,3R,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3, 4-diol
Functional Activity:
Selective A1 adenosine receptor agonist.
Technical Data:
M.Wt: 301.69
Formula: C10H12 ClN5 O4
Solubility: Soluble in DMSO
Purity: >98%
Storage: Dessicate at RT
CAS No.: 146-77-0
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References for 2-Chloroadenosine
1. Dennison, J. B., Ayres, M. L., Kaluarachchi, K., Plunkett, W., and Gandhi, V. Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels. J Biol Chem, 285: 8022-8030.
2. Dennison, J. B., Balakrishnan, K., and Gandhi, V. Preclinical activity of 8-chloroadenosine with mantle cell lymphoma: roles of energy depletion and inhibition of DNA and RNA synthesis. Br J Haematol, 147: 297-307, 2009.
3. Bellezza, I., Tucci, A., and Minelli, A. 2-Chloroadenosine and human prostate cancer cells. Anticancer Agents Med Chem, 8: 783-789, 2008.
4. Bastin-Coyette, L., Smal, C., Cardoen, S., Saussoy, P., Van den Neste, E., and Bontemps, F. Mechanisms of cell death induced by 2-chloroadenosine in leukemic B-cells. Biochem Pharmacol, 75: 1451-1460, 2008.
5. Minelli, A., Bellezza, I., Tucci, A., Conte, C., Bracarda, S., and Culig, Z. 2-chloroadenosine modulates PAR-1 and IL-23 expression and enhances docetaxel effects on PC3 cells. Prostate, 68: 360-372, 2008.
6. Minelli, A., Bellezza, I., Agostini, M., Bracarda, S., and Culig, Z. Mechanism of 2-chloroadenosine toxicity to PC3 cell line. Prostate, 66: 1425-1436, 2006.
7. Koricanac, L. B., Todorovic, D. V., Popovic, N. M., Demajo, M. A., Ruzdijic, S. D., and Ristic-Fira, A. M. Inhibition of B16 mouse melanoma cell growth and induction of apoptotic cell death with 8-chloroadenosine-3',5'-monophosphate and tiazofurin. Ann N Y Acad Sci, 1030: 384-392, 2004.
