Aldosterone
Catalog #:
AG0025| AG0025-5mg | USD60.0 |
Synonyms: Aldosterone , Electrocortin, Aldocortin, Elektrocortin, Aldocorten, Aldocortene, d-Aldosterone, Reichstein X, (+)-Aldosterone, 18-Oxocorticosterone
IUPAC Name:
11β,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
Functional Activity:
Aldosterone is the primary of several endogenous members of the class of mineralocorticoids in humans. Deoxycorticosterone is another important member of this class. Aldosterone tends to promote Na+ and water retention, and lower plasma K+ concentration by the following mechanisms:
1. Acting on the nuclear mineralocorticoid receptors (MR) within the principal cells of the distal tubule and the collecting duct of the kidney nephron, it upregulates and activates the basolateral Na+/K+ pumps, which pumps three sodium ions out of the cell and two potassium ions into the cell. This results in reabsorption of sodium (Na+) ions and water (which follows sodium) into the blood, and secreting potassium (K+) ions into the urine (lumen of collecting duct).
2. Aldosterone upregulates epithelial sodium channel (ENaC) increasing apical membrane permeability for Na+.
3. Cl- is reabsorbed in conjunction with sodium cations to maintain the system's electrochemical balance.
4. Aldosterone stimulates the excretion of K+ into the lumen.
5. Aldosterone stimulates Na+ and water reabsorption from the gut salivary and sweat glands in exchange for K+.
6. Aldosterone stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3-) levels and its acid/base balance.
7. Aldosterone may act on the central nervous system via the posterior pituitary gland to release vasopressin (ADH), which serves to conserve water by direct actions on renal tubular reabsorption.
Technical Data:
M.Wt: 360.44
Formula: C21H28O5
Solubility: Soluble in water
Purity: >97%
Storage: Dessicate at RT
CAS No.: 52-39-1
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References for Aldosterone:
1. Honda, M., Tsukada, T., Horiuchi, T., Tanaka, R., Yamaguchi, K., Obara, T., Miyakawa, H., Yamaji, T., and Ishibashi, M. Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene. Intern Med, 43: 310-314, 2004.
2. Shadyev Kh, D. and Markova, O. V. [Treatment-related aldosterone changes in cancer of the middle part of the larynx]. Vestn Otorinolaringol: 31-32, 1999.
3. Cheng, W. Y., Chang, T. C., Chu, T. S., Tsai, T. C., and Hsieh, H. C. Adrenal cancer with hypertension but low plasma renin and aldosterone. J Formos Med Assoc, 98: 73-75, 1999.
4. Morioka, M., Furukawa, Y., Kobayashi, T., Tanaka, H., Ohashi, Y., and Jin, T. X. Aldosterone-producing adrenal cortical cancer: a case report and analysis of steroidogenic enzymes in the tumor. Endocr J, 44: 547-552, 1997.
5. Shadyev Kh, D. and Markova, O. V. [The changes of serum cortisol and aldosterone in patients with cancer of vestibular section of larynx after irradiation and with and without surgery]. Vestn Otorinolaringol: 43-44, 1997.
6. Shitikov, B. D., Mavrichev, A. S., Sukonko, O. G., Kosheleva, M. I., and Maslova, G. T. [The aldosterone level as a probable prognostic factor in patients with kidney cancer]. Vopr Onkol, 35: 85-86, 1989.
