NMDA
Catalog #:
AG0024| AG0024-25mg | USD40.0 |
Synonyms: NMDA, N-methyl-D-aspartic acid, N-methyl-D-aspartate, N-Methylaspartate, Methyl aspartic acid
IUPAC Name:
(2R)-2-(methylamino)butanedioic acid
Functional Activity:
NMDA is an amino acid derivative which acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors (such as those for AMPA and kainate). NMDA receptors are particularly important when they become overactive during withdrawal from alcohol as this causes symptoms such as agitation and, sometimes, epileptiform seizures.
NMDA is an excitotoxin; but in lower quantities NMDA is not neurotoxic.
Technical Data:
M.Wt: 147.13
Formula: C5H9 N O4
Solubility: Soluble to 100 mM in water
Purity: >99%
Storage: Dessicate at RT
CAS No.: 6384-92-5
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References for NMDA:
1. Suzuki, Y., Kurita, T., Sakurai, K., Takeda, Y., and Koyama, T. [Case report of anti-NMDA receptor encephalitis suspected of schizophrenia]. Seishin Shinkeigaku Zasshi, 111: 1479-1484, 2009.
2. Weigt, H. U., Fohr, K. J., Georgieff, M., Georgieff, E. M., Senftleben, U., and Adolph, O. Xenon blocks AMPA and NMDA receptor channels by different mechanisms. Acta Neurobiol Exp (Wars), 69: 429-440, 2009.
3. Iizuka, T. [Unique clinical features and pathophysiology of anti-NMDA receptor encephalitis]. Rinsho Shinkeigaku, 49: 774-778, 2009.
4. McNearney, T. A., Ma, Y., Chen, Y., Taglialatela, G., Yin, H., Zhang, W. R., and Westlund, K. N. A peripheral neuroimmune link: glutamate agonists upregulate NMDA NR1 receptor mRNA and protein, vimentin, TNF-alpha, and RANTES in cultured human synoviocytes. Am J Physiol Regul Integr Comp Physiol, 298: R584-598.
5. Zandi, M. S., Irani, S. R., Follows, G., Moody, A. M., Molyneux, P., and Vincent, A. Limbic encephalitis associated with antibodies to the NMDA receptor in Hodgkin lymphoma. Neurology, 73: 2039-2040, 2009.
6. Lebas, A., Husson, B., Didelot, A., Honnorat, J., and Tardieu, M. Expanding spectrum of encephalitis with NMDA receptor antibodies in young children. J Child Neurol, 25: 742-745.
