Cinacalcet hydrochloride
Catalog #:
AG0023AG0023-5mg | USD40.0 |
Synonyms: Cinacalcet, Sensipar, Mimpara, AMG-073, Parareg, N-((1R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride

IUPAC Name:
N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1- amine hydrochloride
Functional Activity:
Cinacalcet is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. Cinacalcet is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels), a consequence of having end-stage renal disease. Cinacalcet is also indicated for the treatment of hypercalcemia in patients with parathyroid carcinoma. Most recently, many studies have shown that activation of the calcium-sensing receptor is beneficial to colonic and pancreatic cancers.
Technical Data:
M.Wt: 393.87
Formula: C22H22 F3N.HCl
Solubility: Soluble in DMSO
Purity: >99%
Storage: Dessicate at -20°C
CAS No.: 364782-34-3
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References for Cinacalcet hydrochloride :
1. Kebig, A. and Mohr, K. [Cinacalcet - an allosteric enhancer at the Ca2+-receptor]. Dtsch Med Wochenschr, 133: 1681-1683, 2008.
2. Akinci, B., Comlekci, A., and Tankurt, E. Hypercalcemia of primary hyperparathyroidism was treated by cinacalcet in a patient with liver cirrhosis. Exp Clin Endocrinol Diabetes, 117: 142-145, 2009.
3. Falchetti, A., Cilotti, A., Vaggelli, L., Masi, L., Amedei, A., Cioppi, F., Tonelli, F., and Brandi, M. L. A patient with MEN1-associated hyperparathyroidism, responsive to cinacalcet. Nat Clin Pract Endocrinol Metab, 4: 351-357, 2008.
4. Silverberg, S. J., Rubin, M. R., Faiman, C., Peacock, M., Shoback, D. M., Smallridge, R. C., Schwanauer, L. E., Olson, K. A., Klassen, P., and Bilezikian, J. P. Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma. J Clin Endocrinol Metab, 92: 3803-3808, 2007.
5. Geller, J. L., Khosravi, A., Kelly, M. H., Riminucci, M., Adams, J. S., and Collins, M. T. Cinacalcet in the management of tumor-induced osteomalacia. J Bone Miner Res, 22: 931-937, 2007.
6. Nakanishi, S. and Fukagawa, M. [Therapeutic agents for disorders of bone and calcium metabolism. The calcimimetic cinacalcet HCl]. Clin Calcium, 17: 88-92, 2007.