1-EBIO
Catalog #:
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AG0020-10mg | USD50.0 |
Synonyms: 1-Ethyl-2-benzimidazolinone
IUPAC Name:
1-Ethyl-2-benzimidazolinone
Functional Activity:
Activator of intermediate conductance Ca2+-activated K+ channels.
Technical Data:
M.Wt: 162.19
Formula: C9H10N2O
Solubility: Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity: >99%
Storage: Dessicate at RT
CAS No.: 10045-45-1
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References for 1-EBIO:
1. Roth, E. K., Hirtz, S., Duerr, J., Wenning, D., Eichler, I., Seydewitz, H. H., Amaral, M. D., and Mall, M. A. The K Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients. PLoS One, 6: e24445.
2. Anderson, N. J., Slough, S., and Watson, W. P. In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant. Eur J Pharmacol, 546: 48-53, 2006.
3. Gao, L., Yankaskas, J. R., Fuller, C. M., Sorscher, E. J., Matalon, S., Forman, H. J., and Venglarik, C. J. Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells. Am J Physiol Lung Cell Mol Physiol, 281: L1123-1129, 2001.
4. Hamilton, K. L., Meads, L., and Butt, A. G. 1-EBIO stimulates Cl- secretion by activating a basolateral K+ channel in the mouse jejunum. Pflugers Arch, 439: 158-166, 1999.
5. Edwards, G., Gardener, M. J., Feletou, M., Brady, G., Vanhoutte, P. M., and Weston, A. H. Further investigation of endothelium-derived hyperpolarizing factor (EDHF) in rat hepatic artery: studies using 1-EBIO and ouabain. Br J Pharmacol, 128: 1064-1070, 1999.