TRAM 34
Catalog #:
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Synonyms: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
IUPAC Name:
1-[(2-chlorophenyl)-diphenylmethyl]pyrazole
Functional Activity:
Highly selective blocker of intermediate conductance Ca2+-activated K+ channels (IKCa1, KCa3.1) (Kd = 20 nM).
Technical Data:
M.Wt: 344.84
Formula: C22H17ClN2
Solubility: Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity: >99%
Storage: Dessicate at 4°C
CAS No.: 289905-88-0
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References for TRAM 34:
1. Chen, Y. J., Raman, G., Bodendiek, S., O'Donnell, M. E., and Wulff, H. The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. J Cereb Blood Flow Metab.
2. Roy, J. W., Cowley, E. A., Blay, J., and Linsdell, P. The intermediate conductance Ca2+-activated K+ channel inhibitor TRAM-34 stimulates proliferation of breast cancer cells via activation of oestrogen receptors. Br J Pharmacol, 159: 650-658.
3. Al-Ghananeem, A. M., Abbassi, M., Shrestha, S., Raman, G., Wulff, H., Pereira, L., and Ansari, A. Formulation-based approach to support early drug discovery and development efforts: a case study with enteric microencapsulation dosage form development for a triarylmethane derivative TRAM-34; a novel potential immunosuppressant. Drug Dev Ind Pharm, 36: 563-569.
4. Tharp, D. L., Wamhoff, B. R., Wulff, H., Raman, G., Cheong, A., and Bowles, D. K. Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis. Arterioscler Thromb Vasc Biol, 28: 1084-1089, 2008.
5. Schilling, T. and Eder, C. TRAM-34 inhibits nonselective cation channels. Pflugers Arch, 454: 559-563, 2007.
6. Wulff, H., Gutman, G. A., Cahalan, M. D., and Chandy, K. G. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem, 276: 32040-32045, 2001.
