L-NAME hydrochloride
Catalog #:
IN0098| IN0098-100mg | USD39.0 |
Synonyms: Nω-Nitro-L-arginine methyl ester hydrochloride
IUPAC Name:
methyl (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoate
Functional Activity:
Selective inhibitor of nitric oxide synthase (NOS).
Technical Data:
M.Wt: 269.69
Formula: C7H15 N5 O4.HCl
Solubility: Soluble to 100 mM in water and to 100 mM in DMSO
Purity: >98%
Storage: Dessicate at RT
CAS No.: 51298-62-5
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References for L-NAME hydrochloride:
1. Vanella, L., Di Giacomo, C., Acquaviva, R., Santangelo, R., Cardile, V., Barbagallo, I., Abraham, N. G., and Sorrenti, V. The DDAH/NOS pathway in human prostatic cancer cell lines: antiangiogenic effect of L-NAME. Int J Oncol, 39: 1303-1310.
2. Tsuchiya, K., Tomita, S., Ishizawa, K., Abe, S., Ikeda, Y., Kihira, Y., and Tamaki, T. Dietary nitrite ameliorates renal injury in L-NAME-induced hypertensive rats. Nitric Oxide, 22: 98-103.
3. Reis, O. T., Raini, J. C., Coradi, S. T., and Constantino, D. H. Effect of L-Arginine and L-NAME treatments on polymorphonuclear leukocytes and mononuclear cells influx during tumor growth. Acta Cir Bras, 24: 107-111, 2009.
4. Yamaguchi, H., Kidachi, Y., Umetsu, H., and Ryoyama, K. L-NAME inhibits tumor cell progression and pulmonary metastasis of r/m HM-SFME-1 cells by decreasing NO from tumor cells and TNF-alpha from macrophages. Mol Cell Biochem, 312: 103-112, 2008.
5. Sephashvili, M., Zhuravliova, E., Barbakadze, T., Khundadze, M., Narmania, N., and Mikeladze, D. G. L-NAME has opposite effects on the productions of S-adenosylhomocysteine and S-adenosylmethionine in V12-H-Ras and M-CR3B-Ras pheochromocytoma cells. Neurochem Res, 31: 1205-1210, 2006.
6. Wu, D. and Cederbaum, A. Nitric oxide donors prevent while the nitric oxide synthase inhibitor L-NAME increases arachidonic acid plus CYP2E1-dependent toxicity. Toxicol Appl Pharmacol, 216: 282-292, 2006.
