KT5823
Catalog #:
IN0095| IN0095-0.1mg | USD138.0 |
| IN0095-1mg | USD990.0 |
Synonyms:KT5823, kt5823, KT 5823, LS-172660, 9-Methoxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-epxoy-1H,8H,11H-2,7b-11a-triazadibenzo(a,g)cycloocta(cde)-trinden-1-one
IUPAC Name:
(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
Functional Activity:
Selective inhibitor of protein kinase G (Ki 0.23 μM).
Technical Data:
M.Wt: 495.53
Formula: C29H25N3 O5
Solubility: Soluble to 50 mM in DMSO
Purity: >98%
Storage: Dessicate at -20°C
CAS No.: 126643-37-6
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References for KT5823 :
1. Beyer, S., Lakshmanan, A., Liu, Y. Y., Zhang, X., Wapnir, I., Smolenski, A., and Jhiang, S. KT5823 differentially modulates sodium iodide symporter expression, activity, and glycosylation between thyroid and breast cancer cells. Endocrinology, 152: 782-792.
2. Chan, S. L. and Fiscus, R. R. Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod, 9: 775-783, 2003.
3. Miyoshi, K., Kawakami, N., Horio, S., and Fukui, H. Inhibition of histamine H1 receptor downregulation by KT5823, a protein kinase G inhibitor. Methods Find Exp Clin Pharmacol, 25: 343-347, 2003.
4. Burkhardt, M., Glazova, M., Gambaryan, S., Vollkommer, T., Butt, E., Bader, B., Heermeier, K., Lincoln, T. M., Walter, U., and Palmetshofer, A. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem, 275: 33536-33541, 2000.
5. Wyatt, T. A., Pryzwansky, K. B., and Lincoln, T. M. KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin. Res Commun Chem Pathol Pharmacol, 74: 3-14, 1991.
