KN-62
Catalog #:
IN0094| IN0094-1mg | USD156.0 |
Synonyms: KN-62, KN62, KN 62, 1-(N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl)-4-phenylpiperazine
IUPAC Name:
4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenyl isoquinolinesulfonic acid ester
Functional Activity:
Selective and cell-permeable inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII, IC50 = 0.9 μM).
Technical Data:
M.Wt: 721.84
Formula: C38H35N5 O6S2
Solubility: Soluble to 100 mM in DMSO
Purity: >98%
Storage: Dessicate at -20°C
CAS No.: 127191-97-3
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References for KN-62 :
1. Schuler, A. D., Si, J., Mueller, L., Simon, J. A., and Collins, S. J. KN-62 analogues as potent differentiating agents of HL-60 cells. Leuk Res, 31: 683-689, 2007.
2. Penolazzi, L., Bianchini, E., Lambertini, E., Baraldi, P. G., Romagnoli, R., Piva, R., and Gambari, R. N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts. J Biomed Sci, 12: 1013-1020, 2005.
3. Hubner, K. and Phi-van, L. KN-62, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase II, inhibits the lysozyme pre-mRNA splicing in myelomonocytic HD11 cells. Biochem Biophys Res Commun, 319: 405-409, 2004.
4. Muhl, H., Hofler, S., and Pfeilschifter, J. Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide. Eur J Pharmacol, 482: 325-328, 2003.
5. Baraldi, P. G., del Carmen Nunez, M., Morelli, A., Falzoni, S., Di Virgilio, F., and Romagnoli, R. Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor. J Med Chem, 46: 1318-1329, 2003.
6. Haralambieva, I., Iankov, I., Mitev, V., and Mitov, I. KN-62 enhances Chlamydia pneumoniae-induced p44/p42 mitogen-activated protein kinase activation in murine fibroblasts and attenuates in vitro infection. FEMS Microbiol Lett, 215: 149-155, 2002.
