Staurosporine
Catalog #:
IN0092| IN0092-1mg | USD132.0 |
| IN0092-5mg | USD474.0 |
Synonyms:
IUPAC Name:
[9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Functional Activity:
Broad spectrum protein kinase inhibitor.
Technical Data:
M.Wt: 466.54
Formula: C28H26N4O3
Solubility: Soluble to 50 mM in DMSO
Purity: >98%
Storage: Dessicate at 4°C
CAS No.: 62996-74-1
Related Products by Target:
References for Staurosporine:
1. Jantas, D. and Lason, W. Anti-apoptotic effect of memantine against staurosporine- and low-potassium-induced cell death in cerebellar granule cells: a development-dependent effect. Pharmacol Rep, 61: 827-937, 2009.
2. Avila, C. M., Romeiro, N. C., Sant'Anna, C. M., Barreiro, E. J., and Fraga, C. A. Structural insights into IKKbeta inhibition by natural products staurosporine and quercetin. Bioorg Med Chem Lett, 19: 6907-6910, 2009.
3. Fanucchi, S. and Veale, R. B. Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H. FEBS Lett, 583: 3557-3562, 2009.
4. Faherty, C. S. and Maurelli, A. T. Spa15 of Shigella flexneri is secreted through the type III secretion system and prevents staurosporine-induced apoptosis. Infect Immun, 77: 5281-5290, 2009.
5. Tauskela, J. S. and Brunette, E. Neuroprotection against staurosporine by metalloporphyrins independent of antioxidant capability. Neurosci Lett, 466: 41-46, 2009.
6. Shomin, C. D., Meyer, S. C., and Ghosh, I. Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): optimization and selectivity profiling. Bioorg Med Chem, 17: 6196-6202, 2009.
