FCCP

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Synonyms: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

IUPAC Name:

2-[[4-(trifluoromethoxy)phenyl]hydrazinylidene]propanedinitrile

Functional Activity:

A very potent uncoupler of oxidative phosphorylation in mitochondria.

Technical Data:

M.Wt: 254.17

Formula: C₁₀H₅ F₃N₄O

Solubility: Soluble to 100 mM in DMSO

Purity: >99%

Storage: Dessicate at RT

CAS No.: 370-86-5

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References for FCCP:

1. Monteiro, J. P., Martins, A. F., Lucio, M., Reis, S., Geraldes, C. F., Oliveira, P. J., and Jurado, A. S. Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: a biophysical approach with relevance to mitochondrial uncoupling. J Bioenerg Biomembr, 43: 287-298.

2. To, M. S., Aromataris, E. C., Castro, J., Roberts, M. L., Barritt, G. J., and Rychkov, G. Y. Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca(2+) current in liver cells. Arch Biochem Biophys, 495: 152-158.

3. Pandya, J. D., Pauly, J. R., and Sullivan, P. G. The optimal dosage and window of opportunity to maintain mitochondrial homeostasis following traumatic brain injury using the uncoupler FCCP. Exp Neurol, 218: 381-389, 2009.

4. Han, Y. H., Kim, S. H., Kim, S. Z., and Park, W. H. Carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) as an O2(*-) generator induces apoptosis via the depletion of intracellular GSH contents in Calu-6 cells. Lung Cancer, 63: 201-209, 2009.

5. Pyrtek, L. J. Orlando C. Kirton, MD, FACS, FCCM, FCCP. J Natl Med Assoc, 99: 1420, 2007.

6. Zablockaite, D., Gendviliene, V., Martisiene, I., and Jurevicius, J. Effect of oxidative phosphorylation uncoupler FCCP and F1F0-ATPase inhibitor oligomycin on the electromechanical activity of human myocardium. Adv Med Sci, 52: 89-93, 2007.

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