U-73122
Catalog #:
IN0088| IN0088-5mg | USD89.0 |
Synonyms: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
IUPAC Name:
1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
Functional Activity:
A potent and selective inhibitor of phospholipase C (PLC).
Technical Data:
M.Wt: 464.65
Formula: C29H40 N2O3
Solubility: Soluble to 2 mM in ethanol and to 5 mM in DMSO
Purity: >98%
Storage: Dessicate at RT
CAS No.: 112648-68-7
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References for U-73122:
1. Macmillan, D. and McCarron, J. G. The phospholipase C inhibitor U-73122 inhibits Ca(2+) release from the intracellular sarcoplasmic reticulum Ca(2+) store by inhibiting Ca(2+) pumps in smooth muscle. Br J Pharmacol, 160: 1295-1301.
2. Hollywood, M. A., Sergeant, G. P., Thornbury, K. D., and McHale, N. G. The PI-PLC inhibitor U-73122 is a potent inhibitor of the SERCA pump in smooth muscle. Br J Pharmacol, 160: 1293-1294.
3. Lo Vasco, V. R., Fabrizi, C., Panetta, B., Fumagalli, L., and Cocco, L. Expression pattern and sub-cellular distribution of phosphoinositide specific phospholipase C enzymes after treatment with U-73122 in rat astrocytoma cells. J Cell Biochem, 110: 1005-1012.
4. Badawi, J. K., Seja, T., and Bross, S. In vitro effects of the cyclooxygenase inhibitor indomethacin and of the phospholipase-C inhibitor U-73122 on carbachol-induced contractions of porcine detrusor muscle. Fundam Clin Pharmacol, 22: 667-672, 2008.
5. Chen, Y. J., Sheng, W. Y., Huang, P. R., and Wang, T. C. Potent inhibition of human telomerase by U-73122. J Biomed Sci, 13: 667-674, 2006.
6. Feisst, C., Albert, D., Steinhilber, D., and Werz, O. The aminosteroid phospholipase C antagonist U-73122 (1-[6-[[17-beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrro le-2,5-dione) potently inhibits human 5-lipoxygenase in vivo and in vitro. Mol Pharmacol, 67: 1751-1757, 2005.
