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Catalog #:

IN0088-5mg USD89.0

References for U-73122:

1. Macmillan, D. and McCarron, J. G. The phospholipase C inhibitor U-73122 inhibits Ca(2+) release from the intracellular sarcoplasmic reticulum Ca(2+) store by inhibiting Ca(2+) pumps in smooth muscle. Br J Pharmacol, 160: 1295-1301.

2. Hollywood, M. A., Sergeant, G. P., Thornbury, K. D., and McHale, N. G. The PI-PLC inhibitor U-73122 is a potent inhibitor of the SERCA pump in smooth muscle. Br J Pharmacol, 160: 1293-1294.

3. Lo Vasco, V. R., Fabrizi, C., Panetta, B., Fumagalli, L., and Cocco, L. Expression pattern and sub-cellular distribution of phosphoinositide specific phospholipase C enzymes after treatment with U-73122 in rat astrocytoma cells. J Cell Biochem, 110: 1005-1012.

4. Badawi, J. K., Seja, T., and Bross, S. In vitro effects of the cyclooxygenase inhibitor indomethacin and of the phospholipase-C inhibitor U-73122 on carbachol-induced contractions of porcine detrusor muscle. Fundam Clin Pharmacol, 22: 667-672, 2008.

5. Chen, Y. J., Sheng, W. Y., Huang, P. R., and Wang, T. C. Potent inhibition of human telomerase by U-73122. J Biomed Sci, 13: 667-674, 2006.

6. Feisst, C., Albert, D., Steinhilber, D., and Werz, O. The aminosteroid phospholipase C antagonist U-73122 (1-[6-[[17-beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrro le-2,5-dione) potently inhibits human 5-lipoxygenase in vivo and in vitro. Mol Pharmacol, 67: 1751-1757, 2005.

Certificate of Analysis/MSDS is available upon request with lot number

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