N6-Cyclopentyladenosine
Catalog #:
AG0013| AG0013-25mg | USD52.0 |
Synonyms: N6-Cyclopentyladenosine, CPA, Cyclopentyladenosine
IUPAC Name:
(2R,3R,4S,
5R)-2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
N6-Cyclopentyladenosine is a drug which acts as a selective adenosine A1 receptor agonist (Ki values are 2.3, 790 and 43 nM for human A1, A2A and A3 receptors respectively; EC50 = 18600 nM for hA2B). It has mainly cardiovascular effects with only subtle alterations of behaviour. CPA is widely used in scientific research into the adenosine receptors and has been used to derive a large family of derivatives.
Functional Activity:
Technical Data:
M.Wt: 335.36
Formula: C15H21 N5O4
Solubility: Soluble to 100 mM in 1eq. HCl
Purity: >99%
Storage: Dessicate at 4°C
CAS No.: 41552-82-3
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References for N6-Cyclopentyladenosine:
1. Sufianova, G. Z., Sufianov, A. A., Shapkin, A. G., and Usov, L. A. [Effect of cyclopentyladenosine on the orientation, exploratory, and emotional behavior of rats with model brain injury]. Eksp Klin Farmakol, 72: 20-23, 2009.
2. Dalpiaz, A., Vighi, E., Pavan, B., and Leo, E. Fabrication via a nonaqueous nanoprecipitation method, characterization and in vitro biological behavior of N(6)-cyclopentyladenosine-loaded nanoparticles. J Pharm Sci, 98: 4272-4284, 2009.
3. Dalpiaz, A., Mezzena, M., Scatturin, A., and Scalia, S. Solid lipid microparticles for the stability enhancement of the polar drug N6-cyclopentyladenosine. Int J Pharm, 355: 81-86, 2008.
4. Bakhtiarian, A., Hosseini, M. J., Pousti, A., Behzadmehr, R., Sabzeh-Khah, S., and Najar, F. Effect of n6-cyclopentyladenosine on ouabain-induced toxicity in isolated Guinea pig atria. Toxicol Mech Methods, 18: 581-583, 2008.
5. Girardi, E. S., Canitrot, J., Antonelli, M., Gonzalez, N. N., and Coirini, H. Differential expression of cerebellar metabotropic glutamate receptors mGLUR2/3 and mGLUR4a after the administration of a convulsant drug and the adenosine analogue cyclopentyladenosine. Neurochem Res, 32: 1120-1128, 2007.
6. Maione, S., de Novellis, V., Cappellacci, L., Palazzo, E., Vita, D., Luongo, L., Stella, L., Franchetti, P., Marabese, I., Rossi, F., and Grifantini, M. The antinociceptive effect of 2-chloro-2'-C-methyl-N6-cyclopentyladenosine (2'-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat. Pain, 131: 281-292, 2007.
