Diphenhydramine hydrochloride
Catalog #:
IN0085| IN0085-50mg | USD35.0 |
Synonyms: Diphenhydramine, Dimedrol, Carphenamine, dimedrolum, Sedopretten, Allergan, Bendylate, Benzantine, Carphenex, Cathejell
IUPAC Name:
2-benzhydryloxy-N,N-dimethylethanamine hydrochloride
Diphenhydramine is a histamine H1 receptor antagonist. By blocking histamine in the capillaries it can reduce the intensity of allergic symptoms. Diphenhydramine crosses the blood-brain barrier(BBB) and antagonizes the H1 receptors centrally. Its effects on central H1 receptors causes drowsiness.
Like several other first-generation antihistamines, diphenhydramine is also a potent competitive antagonist of muscarinic cholinergic receptors, and, as such, at high doses can cause anticholinergic syndrome.
Functional Activity:
Technical Data:
M.Wt: 291.82
Formula: C17H21 NO.HCl
Solubility: Soluble in water
Purity: >99%
Storage: Dessicate at RT
CAS No.: 147-24-0
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References for Diphenhydramine hydrochloride:
1. Turner, J. W. Death of a child from topical diphenhydramine. Am J Forensic Med Pathol, 30: 380-381, 2009.
2. Haag, M., Bruning, M., and Molt, K. Quantitative analysis of diphenhydramine hydrochloride in pharmaceutical wafers using near infrared and Raman spectroscopy. Anal Bioanal Chem, 395: 1777-1785, 2009.
3. Gonzalez, F. Diphenhydramine may be useful as a palliative treatment for patients dying with Parkinson's disease and tremors: a case report and discussion. Am J Hosp Palliat Care, 26: 474-475, 2009.
4. Suffridge, P. J., Wiggins, M. N., Landes, R. D., and Harper, R. A. Diphenhydramine as a topical ocular anesthetic. Can J Ophthalmol, 44: 181-184, 2009.
5. Irioka, T., Yamanami, A., Uchida, N., Iwase, M., Yasuhara, H., and Mizusawa, H. Opsoclonus caused by diphenhydramine self-poisoning. J Neuroophthalmol, 29: 72-73, 2009.
6. Banks, M. L., Andersen, M. L., Murnane, K. S., Meyer, R. C., and Howell, L. L. Behavioral and neurochemical effects of cocaine and diphenhydramine combinations in rhesus monkeys. Psychopharmacology (Berl), 205: 467-474, 2009.
