NPPB
Catalog #:
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Synomyms: NPPB, 5-Nitro-2-(3-phenylpropylamino)benzoic acid, 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid, Benzoic acid
IUPAC Name:
5-nitro-2-(3-phenylpropylamino)benzoic acid
NPPB is a potent chloride channel blocker. Putative GPR35 agonist.
Functional Activity:
Technical Data:
M.Wt: 300.31
Formula: C16H16N2O4
Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity: >98%
Storage: Dessicate at -20°C
CAS No.: 107254-86-4
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References for NPPB:
1. Fujimoto, S., Niisato, N., Sugimoto, T., and Marunaka, Y. Quercetin and NPPB-induced diminution of aldosterone action on Na+ absorption and ENaC expression in renal epithelium. Biochem Biophys Res Commun, 336: 401-407, 2005.
2. Graichen, F., Giles, K. R., Abell, A., and Garrill, A. Removal of the nitro and phenyl groups from NPPB decreases its inhibitory effect on cytoplasmic streaming in the alga Nitella hookeri. Biochem Cell Biol, 83: 133-139, 2005.
3. Fioretti, B., Castigli, E., Calzuola, I., Harper, A. A., Franciolini, F., and Catacuzzeno, L. NPPB block of the intermediate-conductance Ca2+-activated K+ channel. Eur J Pharmacol, 497: 1-6, 2004.
4. Myssina, S., Lang, P. A., Kempe, D. S., Kaiser, S., Huber, S. M., Wieder, T., and Lang, F. Cl- channel blockers NPPB and niflumic acid blunt Ca(2+)-induced erythrocyte 'apoptosis'. Cell Physiol Biochem, 14: 241-248, 2004.
5. Giles, K. R., Humphries, M., Abell, A., and Garrill, A. The synthesis of NPPB and NPBB by reductive amination and the effects of these compounds on K+ channels of the alga Nitella hookeri. Bioorg Med Chem Lett, 13: 293-295, 2003.
6. Zhang, Z. R., Zeltwanger, S., and McCarty, N. A. Direct comparison of NPPB and DPC as probes of CFTR expressed in Xenopus oocytes. J Membr Biol, 175: 35-52, 2000.
