Suramin Sodium Salt
Catalog #:
IN0077| IN0077-250mg | USD170.0 |
| IN0077-1g | USD402.0 |
Synonyms: Suramin, Suramin sodium, Suramin hexasodium, Antrypol, Moranyl, Naganinum, Naphuride sodium, Naganine, Sodium suramin
IUPAC Name:
hexasodium 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6, 8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl] carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3, 5-trisulfonate
Functional Activity:
Non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Anticancer and antiviral agent.
Technical Data:
M.Wt: 1429.15
Formula: C51H34 N6Na6O23 S6
Solubility: Soluble in water and in DMSO
Purity: >97%
Storage: Dessicate at RT
CAS No.: 129-46-4
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References for Suramin sodium salt:
1. Sener, M., Akhan, S., Kazimoglu, C., Karapinar, H., Tuna, B., and Cecen, B. The effects of suramin in prevention of peritendinous adhesions following flexor tendon injury in a chicken model. Orthopedics, 31: 542, 2008.
2. Cetinkaya, A., Akman, A., Take, G., Bilezikci, B., and Akova, Y. A. Ciliary body toxicity of subconjunctival suramin compared with mitomycin-C in the rabbit eye: determining the toxic concentration. Ophthalmic Res, 41: 91-97, 2009.
3. McGeary, R. P., Bennett, A. J., Tran, Q. B., Cosgrove, K. L., and Ross, B. P. Suramin: clinical uses and structure-activity relationships. Mini Rev Med Chem, 8: 1384-1394, 2008.
4. Galgoczy, L., Papp, T., and Vagvolgyi, C. In vitro interaction between suramin and fluvastatin against clinically important Zygomycetes. Mycoses, 52: 447-453, 2009.
5. Zhuang, S., Lu, B., Daubert, R. A., Chavin, K. D., Wang, L., and Schnellmann, R. G. Suramin promotes recovery from renal ischemia/reperfusion injury in mice. Kidney Int, 75: 304-311, 2009.
6. George, S., Dreicer, R., Au, J. J., Shen, T., Rini, B. I., Roman, S., Cooney, M. M., Mekhail, T., Elson, P., Wientjes, G. M., Ganapathi, R., and Bukowski, R. M. Phase I/II trial of 5-fluorouracil and a noncytotoxic dose level of suramin in patients with metastatic renal cell carcinoma. Clin Genitourin Cancer, 6: 79-85, 2008.
