Serotonin hydrochloride

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Synonyms: Serotonin, 5-Hydroxytryptamine, Serotonin hydrochloride, 5-HT, Enteramine, Thrombocytin, 5-hydroxytryptamine

IUPAC Name:

3-(2-aminoethyl)-1H-indol-5-ol hydrochloride

Functional Activity:

Serotonin is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal (GI) tract, platelets, and in the central nervous system (CNS) of animals including humans. It is a well-known contributor to feelings of well-being; it is also known to contribute to happiness.

Serotonin is a neurotransmitter, and is found in all bilateral animals, where it mediates gut movements and the animal's perception of resource availability. In the simplest animals, resources are equivalent with food, but in advanced animals such as arthropods and vertebrates, resources also can mean social dominance. In response to the perceived abundance or scarcity of resources, the animal's growth, reproduction or mood may be elevated or lowered. Recent studies involving the serotonin transporter gene 5-HTT have shown the short allele of this gene increases synaptic serotonin levels. These genetic studies have demonstrated serotonin has strong associations with depression in regards to a negative environment.

Technical Data:

M.Wt: 212.68

Formula: C₁₀H₁₃N₂OCl

Solubility: Soluble in water and in DMSO

Purity: >99%

Storage: Dessicate at 4°C

CAS No.: 153-98-0

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References for Serotonin hydrochloride:

1. Nukuzuma, S., Nakamichi, K., Nukuzuma, C., and Takegami, T. Inhibitory effect of serotonin antagonists on JC virus propagation in a carrier culture of human neuroblastoma cells. Microbiol Immunol, 53: 496-501, 2009.

2. Drozdov, I., Kidd, M., Gustafsson, B. I., Svejda, B., Joseph, R., Pfragner, R., and Modlin, I. M. Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines. Cancer, 115: 4934-4945, 2009.

3. Amit, B. H., Gil-Ad, I., Taler, M., Bar, M., Zolokov, A., and Weizman, A. Proapoptotic and chemosensitizing effects of selective serotonin reuptake inhibitors on T cell lymphoma/leukemia (Jurkat) in vitro. Eur Neuropsychopharmacol, 19: 726-734, 2009.

4. Slotkin, T. A., Wrench, N., Ryde, I. T., Lassiter, T. L., Levin, E. D., and Seidler, F. J. Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood. Neurotoxicol Teratol, 31: 390-399, 2009.

5. Dai, W., Renagul, A., Hamulati, W., and Peng, X. [Study of serotonin transporter gene polymorphisms in disease of patients with abnormal black Savda]. Wei Sheng Yan Jiu, 38: 265-269, 2009.

6. Froberg, G. K., Lindberg, R., Ritter, M., and Nordlind, K. Expression of serotonin and its 5-HT1A receptor in canine cutaneous mast cell tumours. J Comp Pathol, 141: 89-97, 2009.

Certificate of Analysis/MSDS is available upon request with lot number