Histamine dihydrochloride
Catalog #:
AG0006| AG0006-50mg | USD30.0 |
Synonyms: Histamine, Peremin, Ceplene, Histamine chloride, Histamine dichloride, Histaminedium dichloride
IUPAC Name:
2-(1H-imidazol-5-yl)ethanamine dihydrochloride
Functional Activity:
Histamine is an organic nitrogen compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine triggers the inflammatory response. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues.
Technical Data:
M.Wt: 184.07
Formula: C5H9 N3.2HCl
Solubility: Soluble in water and in DMSO
Purity: >99%
Storage: Dessicate at RT
CAS No.: 56-92-8
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References for Histamine dihydrochloride:
1. Szabo, P. M., Wiener, Z., Tombol, Z., Kovacs, A., Pocza, P., Horanyi, J., Kulka, J., Riesz, P., Toth, M., Patocs, A., Gaillard, R. C., Falus, A., Racz, K., and Igaz, P. Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumors. Virchows Arch, 455: 133-142, 2009.
2. Pierson, P. D., Fettes, A., Freichel, C., Gatti-McArthur, S., Hertel, C., Huwyler, J., Mohr, P., Nakagawa, T., Nettekoven, M., Plancher, J. M., Raab, S., Richter, H., Roche, O., Rodriguez Sarmiento, R. M., Schmitt, M., Schuler, F., Takahashi, T., Taylor, S., Ullmer, C., and Wiegand, R. 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity. J Med Chem, 52: 3855-3868, 2009.
3. Fioretti, B., Catacuzzeno, L., Sforna, L., Aiello, F., Pagani, F., Ragozzino, D., Castigli, E., and Franciolini, F. Histamine hyperpolarizes human glioblastoma cells by activating the intermediate-conductance Ca2+-activated K+ channel. Am J Physiol Cell Physiol, 297: C102-110, 2009.
4. von Mach-Szczypinski, J., Stanosz, S., Sieja, K., and Stanosz, M. Metabolism of histamine in tissues of primary ductal breast cancer. Metabolism, 58: 867-870, 2009.
5. Clark, K., Lam, L., and Currow, D. Reducing gastric secretions--a role for histamine 2 antagonists or proton pump inhibitors in malignant bowel obstruction? Support Care Cancer, 17: 1463-1468, 2009.
6. Medina, V. A., Massari, N. A., Cricco, G. P., Martin, G. A., Bergoc, R. M., and Rivera, E. S. Involvement of hydrogen peroxide in histamine-induced modulation of WM35 human malignant melanoma cell proliferation. Free Radic Biol Med, 46: 1510-1515, 2009.
