Progesterone
Catalog #:
AG0005| AG0005-100mg | USD45.0 |
Synonyms: Progesterone, Luteohormone, Syngesterone, Agolutin, Cyclogest, Utrogestan, Crinone, Luteol, Hormoflaveine, Methylpregnone
IUPAC Name:
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Functional Activity:
Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestogens, and is the major naturally occurring human progestogen. It is an endogenous progesterone receptor agonist (EC50 = 0.5 nM).
Progesterone is commonly manufactured from the yam family, Dioscorea. Dioscorea produces large amounts of a steroid called diosgenin, which can be converted into progesterone in the laboratory.
Technical Data:
M.Wt: 314.46
Formula: C21H30 NO2
Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity: >98%
Storage: Dessicate at RT
CAS No.: 57-83-0
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References for Progesterone:
1. Lanari, C., Lamb, C. A., Fabris, V. T., Helguero, L. A., Soldati, R., Bottino, M. C., Giulianelli, S., Cerliani, J. P., Wargon, V., and Molinolo, A. The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer. Endocr Relat Cancer, 16: 333-350, 2009.
2. Lai, J., Myers, S. A., Lawrence, M. G., Odorico, D. M., and Clements, J. A. Direct progesterone receptor and indirect androgen receptor interactions with the kallikrein-related peptidase 4 gene promoter in breast and prostate cancer. Mol Cancer Res, 7: 129-141, 2009.
3. Orbo, A., Moe, B. T., Gronaas, H., and Paulssen, R. H. Early effects of high concentrations of progesterone and mifepristone A gene expression study of endometrial cancer cells (Ishikawa). J Steroid Biochem Mol Biol, 113: 139-149, 2009.
4. Linderholm, B., Bergqvist, J., Hellborg, H., Johansson, U., Linderholm, M., von Schoultz, E., Elmberger, G., Skoog, L., and Bergh, J. Shorter survival-times following adjuvant endocrine therapy in oestrogen- and progesterone-receptor positive breast cancer overexpressing HER2 and/or with an increased expression of vascular endothelial growth factor. Med Oncol, 26: 480-490, 2009.
5. Dressing, G. E. and Lange, C. A. Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferation. Steroids, 74: 573-576, 2009.
6. Kim, J. J., Sefton, E. C., and Bulun, S. E. Progesterone receptor action in leiomyoma and endometrial cancer. Prog Mol Biol Transl Sci, 87: 53-85, 2009.
