Ryanodine
Catalog #:
IN0071| IN0071-1mg | USD162.0 |
| IN0071-5mg | USD630.0 |
Synonyms: Ryanodine, Ryanadol, 3-(1H-pyrrole-2-carboxylate
IUPAC Name:
1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS) -dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-tri methyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pent aleno[1,6-bc]furan-8-yl ester
Functional Activity:
Ryanodine is a poisonous alkaloid found in the South American plant Ryania speciosa (Flacourtiaceae). It was originally used as an insecticide.
The compound has extremely high affinity to the ryanodine receptor, a group of calcium channels found in skeletal and heart muscle cells. It binds with such high affinity to the receptor that it was used as a label for the first purification of that class of ion channels and gave its name to it. Potent inhibitor of Ca2+ release from sarcoplasmic reticulum (IC50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).
Technical Data:
M.Wt: 493.55
Formula: C25H35 NO9
Solubility: Soluble to 10 mM in ethanol
Purity: >98%
Storage: Dessicate at RT
CAS No.: 15662-33-6
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References for Ryanodine:
1. Amador, F. J., Liu, S., Ishiyama, N., Plevin, M. J., Wilson, A., MacLennan, D. H., and Ikura, M. Crystal structure of type I ryanodine receptor amino-terminal beta-trefoil domain reveals a disease-associated mutation "hot spot" loop. Proc Natl Acad Sci U S A, 106: 11040-11044, 2009.
2. Saldana, C., Diaz-Munoz, M., Antaramian, A., Gonzalez-Gallardo, A., Garcia-Solis, P., and Morales-Tlalpan, V. MCF-7 breast carcinoma cells express ryanodine receptor type 1: functional characterization and subcellular localization. Mol Cell Biochem, 323: 39-47, 2009.
3. Abdul, M., Ramlal, S., and Hoosein, N. Ryanodine receptor expression correlates with tumor grade in breast cancer. Pathol Oncol Res, 14: 157-160, 2008.
4. Newmark, J. L., Voelkel, M., Brandom, B. W., and Wu, J. Delayed onset of malignant hyperthermia without creatine kinase elevation in a geriatric, ryanodine receptor type 1 gene compound heterozygous patient. Anesthesiology, 107: 350-353, 2007.
5. Cui, L. Y., Li, Y. F., Li, Y. H., and Zhang, J. B. [Determination and clinical significance of serum anti-ryanodine receptor antibody in patients with myasthenia gravis]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 29: 238-240, 2007.
6. Hashii, M., Shuto, S., Fukuoka, M., Kudoh, T., Matsuda, A., and Higashida, H. Amplification of depolarization-induced and ryanodine-sensitive cytosolic Ca2+ elevation by synthetic carbocyclic analogs of cyclic ADP-ribose and their antagonistic effects in NG108-15 neuronal cells. J Neurochem, 94: 316-323, 2005.
