Caffeine
Catalog #:
AG0001| AG0001-100mg | USD25.0 |
Synonyms: Caffeine, Caffein, 1,3,7-Trimethylxanthine, Trimethylxanthine, Methyltheobromine, 7-Methyltheophylline, Mateine, Guaranine
IUPAC Name:
1,3,7-trimethyl-1H-purine-2,6(3H,7H)-dione
Functional Activity:
Caffeine is a Ryanidine activator and it also acts as a central nervous system stimulant, temporarily warding off drowsiness and restoring alertness. It is the world's most widely consumed psychoactive drug, but, unlike many other psychoactive substances, it is legal and unregulated in nearly all parts of the world. It is an antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Caffeine mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.
Technical Data:
M.Wt: 194.19
Formula: C8H10 N4O2
Solubility: Soluble to 100 mM in water and to 50 mM in DMSO
Purity: >99%
Storage: Dessicate at RT
CAS No.: 58-08-2
Special Conditions:
This product is a Dangerous Good (UN1544) and carries a $10 dangerous goods packaging fee.
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References for Caffeine:
1. Kerzendorfer, C. and O'Driscoll, M. UVB and caffeine: inhibiting the DNA damage response to protect against the adverse effects of UVB. J Invest Dermatol, 129: 1611-1613, 2009.
2. Hayashi, K., Tsuchiya, H., Yamamoto, N., Shirai, T., Yamauchi, K., Takeuchi, A., Kawahara, M., Miyamoto, K., and Tomita, K. Impact of serum caffeine monitoring on adverse effects and chemotherapeutic responses to caffeine-potentiated chemotherapy for osteosarcoma. J Orthop Sci, 14: 253-258, 2009.
3. Kotsopoulos, J., Eliassen, A. H., Missmer, S. A., Hankinson, S. E., and Tworoger, S. S. Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women. Cancer, 115: 2765-2774, 2009.
4. Heffernan, T. P., Kawasumi, M., Blasina, A., Anderes, K., Conney, A. H., and Nghiem, P. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Invest Dermatol, 129: 1805-1815, 2009.
5. Kurahashi, N., Inoue, M., Iwasaki, M., Sasazuki, S., and Tsugane, S. Coffee, green tea, and caffeine consumption and subsequent risk of bladder cancer in relation to smoking status: a prospective study in Japan. Cancer Sci, 100: 294-291, 2009.
6. Kotsopoulos, J., Vitonis, A. F., Terry, K. L., De Vivo, I., Cramer, D. W., Hankinson, S. E., and Tworoger, S. S. Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer. Cancer Causes Control, 20: 335-344, 2009.
