Ionomycin, Calcium Salt

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Synomyms: ionomycin

IUPAC Name:

Calcium (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-[(2S, 5S)-5-[(2R, 5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4, 6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate

Functional Activity:

Used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. Ca²⁺ ionophore that is more effective than A23187 as a mobile ion carrier for Ca²⁺; non-fluorescent; used to study Ca²⁺ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.

Technical Data:

M.Wt: 747.08

Formula: C₄₁H₇₀ O₉Ca

Solubility: Soluble to 100 mM in ethanol and to 25 mM in DMSO

Purity: >98%

Storage: Dessicate at -20°C

CAS No.: 56092-82-1

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References for Ionomycin:

1. Villaverde, A. I., Fioratti, E. G., Landim-Alvarenga, F. C., de Carvalho Balieiro, J. C., Melo, C. M., Papa, F. O., and Lopes, M. D. Effect of progesterone and ionomycin on domestic cat sperm motility patterns and acrosome reaction. Reprod Domest Anim, 44 Suppl 2: 309-312, 2009.

2. Gao, Z., Li, Y., Cooksey, J. P., Snaddon, T. N., Schunk, S., Viseux, E. M., McAteer, S. M., and Kocienski, P. J. A synthesis of an ionomycin calcium complex. Angew Chem Int Ed Engl, 48: 5022-5025, 2009.

3. Abdalla, H., Shimoda, M., Hirabayashi, M., and Hochi, S. A combined treatment of ionomycin with ethanol improves blastocyst development of bovine oocytes harvested from stored ovaries and microinjected with spermatozoa. Theriogenology, 72: 453-460, 2009.

4. Le, H. K., Graham, L., Miller, C. H., Kmieciak, M., Manjili, M. H., and Bear, H. D. Incubation of antigen-sensitized T lymphocytes activated with bryostatin 1 + ionomycin in IL-7 + IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2. Cancer Immunol Immunother, 58: 1565-1576, 2009.

5. Devito, L. G., Fernandes, C. B., Blanco, I. D., Tsuribe, P. M., and Landim-Alvarenga, F. C. Use of a Piezo drill for intracytoplasmic sperm injection into cattle oocytes activated with ionomycin associated with roscovitine. Reprod Domest Anim, 45: 654-658.

6. Higai, K., Tsukada, M., Moriya, Y., Azuma, Y., and Matsumoto, K. Prolonged high glucose suppresses phorbol 12-myristate 13-acetate and ionomycin-induced interleukin-2 mRNA expression in Jurkat cells. Biochim Biophys Acta, 1790: 8-15, 2009.

Certificate of Analysis/MSDS is available upon request with lot number