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Catalog #:

IN0067-1mg USD40.0
IN0067-5mg USD230.0
IN0067-10mg USD430.0

References for Thapsigargin :

1. Vander Griend, D. J., Antony, L., Dalrymple, S. L., Xu, Y., Christensen, S. B., Denmeade, S. R., and Isaacs, J. T. Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells. Mol Cancer Ther, 8: 1340-1349, 2009.

2. Lee, T. J., Lee, J. T., Kim, S. H., Choi, Y. H., Song, K. S., Park, J. W., and Kwon, T. K. Overexpression of Par-4 enhances thapsigargin-induced apoptosis via down-regulation of XIAP and inactivation of Akt in human renal cancer cells. J Cell Biochem, 103: 358-368, 2008.

3. Lee, D. I., Sumbilla, C., Lee, M., Natesavelalar, C., Klein, M. G., Ross, D. D., Inesi, G., and Hussain, A. Mechanisms of resistance and adaptation to thapsigargin in androgen-independent prostate cancer PC3 and DU145 cells. Arch Biochem Biophys, 464: 19-27, 2007.

4. O'Neill, J. P., Velalar, C. N., Lee, D. I., Zhang, B., Nakanishi, T., Tang, Y., Selaru, F., Ross, D., Meltzer, S. J., and Hussain, A. Thapsigargin resistance in human prostate cancer cells. Cancer, 107: 649-659, 2006.

5. Denmeade, S. R., Jakobsen, C. M., Janssen, S., Khan, S. R., Garrett, E. S., Lilja, H., Christensen, S. B., and Isaacs, J. T. Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer. J Natl Cancer Inst, 95: 990-1000, 2003.

6. Yamaguchi, H., Bhalla, K., and Wang, H. G. Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. Cancer Res, 63: 1483-1489, 2003.

Certificate of Analysis/MSDS is available upon request with lot number

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