DNDS

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Synomyms: DNDS, 4,4'-dinitrostilbene-2,2'-disulfonic acid disodium salt, Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis(5-nitro-, disodium salt, disodium 5-nitro-2-[(E)-2-(4-nitro-2-sulfonatophenyl)ethenyl]benzenesulfonate

IUPAC Name:

disodium 5-nitro-2-[(E)-2-(4-nitro-2-sulfonatophenyl)ethenyl]benzenesulfonate

Functional Activity:

Inhibitor of HCO₃-dependent anion transporters (NBC)

Technical Data:

M.Wt: 474.34

Formula: C₁₄H₈N₂Na₂O₁₀S₂

Solubility: Soluble to 100 mM in DMSO

Purity: >97%

Storage: Dessicate at RT

CAS No.: 3709-43-1

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References for DNDS:

1. O'Neill, E. R., Sakowska, M. M., and Laver, D. R. Regulation of the calcium release channel from skeletal muscle by suramin and the disulfonated stilbene derivatives DIDS, DBDS, and DNDS. Biophys J, 84: 1674-1689, 2003.

2. Liu, S. Q., Ries, E., and Knauf, P. A. Effects of external pH on binding of external sulfate, 4.4-dinitro-stilbene-2,2'-disulfonate (DNDS), and chloride to the band 3 anion exchange protein. J Gen Physiol, 107: 293-306, 1996.

3. Boron, W. F. and Knakal, R. C. Intracellular pH-regulating mechanism of the squid axon. Interaction between DNDS and extracellular Na+ and HCO3. J Gen Physiol, 93: 123-150, 1989.

4. Frohlich, O. The external anion binding site of the human erythrocyte anion transporter: DNDS binding and competition with chloride. J Membr Biol, 65: 111-123, 1982.

Certificate of Analysis/MSDS is available upon request with lot number