Verapamil hydrochloride
Catalog #:
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Synonyms: Verapamil, 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochlorid, Isoptin, Verelan, Calan, Bosoptin, Covera-HS, Verapamil HCl, Cardibeltin, Manidon , Calcan hydrochloride, Verapamyl hydrochloride , Cardioprotect
IUPAC Name:
2-(3,4-dimethoxyphenyl)-5-[2-(3, 4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile hydrochlorideFunctional Activity:
Verapamil is an L-type calcium channel blocker of the phenylalkylamine class. It is also a vasodilator, adrenergic antagonist. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and most recently, cluster headaches. It is also an effective preventive medication for migraine. Verapamil has also been used as a vasodilator during cryopreservation of blood vessels. It is a class IV antiarrhythmic, more effective than digoxin in controlling ventricular rate.
Technical Data:
M.Wt: 491.07
Formula: C27H38N2O4
Solubility: Soluble in 50mg/mL in water and soluble in ethanol
Purity: >99%
Storage: Dessicate at RT
CAS No.: 152-11-4
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References for Verapamil hydrochloride:
1. Matsumura, C. Y., Pertille, A., Albuquerque, T. C., Santo Neto, H., and Marques, M. J. Diltiazem and verapamil protect dystrophin-deficient muscle fibers of MDX mice from degeneration: a potential role in calcium buffering and sarcolemmal stability. Muscle Nerve, 39: 167-176, 2009.
2. Sahoo, J., Murthy, P. N., Biswal, S., and Manik Formulation of sustained-release dosage form of verapamil hydrochloride by solid dispersion technique using Eudragit RLPO or Kollidon SR. AAPS PharmSciTech, 10: 27-33, 2009.
3. Bansal, T., Mishra, G., Jaggi, M., Khar, R. K., and Talegaonkar, S. Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats. Eur J Pharm Sci, 36: 580-590, 2009.
4. Versari, D., Virdis, A., Ghiadoni, L., Daghini, E., Duranti, E., Masi, S., Magagna, A., and Taddei, S. Effect of verapamil, trandolapril and their combination on vascular function and structure in essential hypertensive patients. Atherosclerosis, 205: 214-220, 2009.
5. Tfelt-Hansen, P. and Tfelt-Hansen, J. Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache, 49: 117-125, 2009.
6. Benlier, E., Unal, Y., Usta, U., Top, H., and Aygit, A. C. Effect of verapamil on reduction of peri-implant capsular thickness. Aesthetic Plast Surg, 33: 570-575, 2009.
