SK&F96365
Catalog #:
IN0060Shipping advice:
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Synonyms: SK&F96365, 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole, 1-[β-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenethyl]-1H-imidazole hydrochloride, 130495-35-1, AC1L2XS8, SKF-96365, Hydrochloride
IUPAC Name:
1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole hydrochlorideFunctional Activity:
It is a store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also inhibits TRP channels, voltage-gated Ca2+ channels and potassium channels. In circular smooth muscle bundles isolated from the guinea-pig stomach antrum, the effects of quinidine, Ni2+, flufenamic acid, niflumic acid, La3+, SK&F96365, and DIDS on acetylcholine (ACh)-induced depolarization were investigated. SK&F96365 (3-50 μM) depolarized the membrane in a concentration-dependent manner, but did not change the level of ACh-induced depolarization. These results provide evidence that ACh-induced depolarization is not inhibited by chemicals known to inhibit non-selective cation channels.
Technical Data:
M.Wt: 402.92
Formula: C22H26 N2O3.HCl
Solubility: Soluble to 100 mM in water
Purity: >98%
Storage: Dessicate at 4°C
CAS No.: 130495-35-1
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References for SK&F96365:
1. Singh, A., Hildebrand, M. E., Garcia, E., and Snutch, T. P. The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. Br J Pharmacol, 160: 1464-1475.
2. Kindzelskii, A. L. and Petty, H. R. Ion channel clustering enhances weak electric field detection by neutrophils: apparent roles of SKF96365-sensitive cation channels and myeloperoxidase trafficking in cellular responses. Eur Biophys J, 35: 1-26, 2005.
