Nifedipine
Catalog #:
IN0058Shipping advice:
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Synonyms: Nifedipine, Adalat, Nifediac, Cordipin, Nifedical, Procardia
IUPAC Name:
3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylateFunctional Activity:
Nifedipine is a dihydropyridine L-type calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal's angina) and antihypertensive, although a large number of other indications have recently been found for this agent, such as Raynaud's phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers.
Technical Data:
M.Wt: 346.34
Formula: C17H18N2O6
Solubility: Soluble to 100 mM in DMSO
Purity: >99%
Storage: Dessicate at 4°C
CAS No.: 21829-25-4
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References for Nifedipine:
1. Matsui, T., Yamagishi, S., Takeuchi, M., Ueda, S., Fukami, K., and Okuda, S. Nifedipine, a calcium channel blocker, inhibits advanced glycation end product (AGE)-elicited mesangial cell damage by suppressing AGE receptor (RAGE) expression via peroxisome proliferator-activated receptor-gamma activation. Biochem Biophys Res Commun, 385: 269-272, 2009.
2. Ohshima, H., Miyagishima, A., Kurita, T., Makino, Y., Iwao, Y., Sonobe, T., and Itai, S. Freeze-dried nifedipine-lipid nanoparticles with long-term nano-dispersion stability after reconstitution. Int J Pharm, 377: 180-184, 2009.
3. Zhang, Y., Hong, X., Liu, H., Huo, Y., and Xu, X. Arg347Cys polymorphism of alpha1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients. J Hum Genet, 54: 360-364, 2009.
4. Zhang, Z. Q., Shi, B., Wu, G. Q., Qin, K. R., Jiang, Z. L., and Zhu, L. Combined use of propranolol and nifedipine offers better effects on portal vein nonuniform remodeling in carbon tetrachloride (CCl(4))-induced portal hypertensive rats. Eur J Pharmacol, 613: 108-113, 2009.
5. Nassar, A. H., Abu-Musa, A. A., Awwad, J., Khalil, A., Tabbara, J., and Usta, I. M. Two dose regimens of nifedipine for management of preterm labor: a randomized controlled trial. Am J Perinatol, 26: 575-581, 2009.
6. Fukuda, M., Masuda, T., Ogura, M. N., Moriya, T., Tanaka, K., Yamamoto, K., Ishii, A., Yonezawa, R., Noda, C., and Izumi, T. Influence of nifedipine coat-core and amlodipine on systemic arterial stiffness modulated by sympathetic and parasympathetic activity in hypertensive patients. Hypertens Res, 32: 392-398, 2009.
