Glybenclamide
Catalog #:
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Synonyms: Glybenclamide, Glibenclamide, INN, glyburide, 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide, Glyburide, N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N’-cyclohexylurea
IUPAC Name:
5-chloro-N-(4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)-2-methoxybenzamideFunctional Activity:
Selectively blocks ATP-sensitive K+ channels; high affinity binding sites found in brain, pancreatic β cells, and cardiovascular system. It is used in the treatment of type II diabetes. In the United States, it was the most popular sulfonylurea. Additionally, recent research shows that Glybenclamide improves outcome in animal stroke models by preventing brain swelling. A retrospective study showed that in type 2 diabetic patients already taking Glybenclamide, there was improved NIH stroke scale scores on discharge compared to diabetic patients not taking Glybenclamide.
Technical Data:
M.Wt: 494.00
Formula: C23H28ClN3O5S
Solubility: Soluble in 100 mM in DMSO
Purity: >99%
Storage: Dessicate at 4 ° C
CAS No.: 10238-21-8
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References for Glybenclamide :
1. Ting, H. J. and Khasawneh, F. T. Glybenclamide: an antidiabetic with in vivo antithrombotic activity. Eur J Pharmacol, 649: 249-254.
2. Ting, H. J., Murray, W. J., and Khasawneh, F. T. Repurposing an old drug for a new use: glybenclamide exerts antiplatelet activity by interacting with the thromboxane A(2) receptor. Acta Pharmacol Sin, 31: 150-159.
3. Moura, M. R., de Nucci, G., Rath, S., and Reyes, F. G. LC-APCI-MS-MS methodology for determination of glybenclamide in human plasma. Anal Bioanal Chem, 378: 499-503, 2004.
4. Hsieh, S. and Selinger, K. High-throughput bioanalytical method using automated sample preparation and liquid chromatography-atmospheric pressure ionspray mass spectrometry for quantitative determination of glybenclamide in human serum. J Chromatogr B Analyt Technol Biomed Life Sci, 772: 347-356, 2002.
5. Ju, Y. K. and Saint, D. A. Subconductance states of the cardiac K(ATP) channel revealed by partial block with glybenclamide. Pflugers Arch, 442: 867-873, 2001.
6. Hernandez-Benito, M. J., Macianskiene, R., Sipido, K. R., Flameng, W., and Mubagwa, K. Suppression of transient outward potassium currents in mouse ventricular myocytes by imidazole antimycotics and by glybenclamide. J Pharmacol Exp Ther, 298: 598-606, 2001.
