Bepridil hydrochloride
Catalog #:
IN0051Shipping advice:
Suitable for Standard Delivery only (2-3 days). International shipping rate please contact us for details
IN0052-100mg | USD100.0 |
Synonyms: Vascor
IUPAC Name:
N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline hydrochlorideFunctional Activity:
Bepridil is a calcium channel blocker once used to treat angina. It also blocks Na+/Ca2+ exchanger (NCX), sodium and KATP channels. Anti-arrhythmic and antihypertensive.
Technical Data:
M.Wt: 403.00
Formula: C24H35N2O.HCl
Solubility: Soluble to 100 mM in DMSO
Purity: >97%
Storage: Dessicate at RT
CAS No.: 74764-40-2
Related Products by Target:
References for Bepridil hydrochloride :
1. Suzuki, T., Hanaoka, M., Yokoyama, T., Koizumi, T., and Kubo, K. Gradual progression of interstitial pneumonia induced by bepridil. Intern Med, 48: 2033-2035, 2009.
2. Miyazaki, S., Kuwahara, T., Kobori, A., Takahashi, Y., Takei, A., Sato, A., Isobe, M., and Takahashi, A. Pharmacological cardioversion preceding left atrial ablation: bepridil predicts the clinical outcome following ablation in patients with persistent atrial fibrillation. Europace, 11: 1620-1623, 2009.
3. Osaka, T., Yokoyama, E., Kushiyama, Y., Hasebe, H., Kuroda, Y., Suzuki, T., and Kodama, I. Opposing effects of bepridil on ventricular repolarization in humans. Inhomogeneous prolongation of the action potential duration vs flattening of its restitution kinetics. Circ J, 73: 1612-1618, 2009.
4. Hirao, K. Does bepridil create a paradigm shift in the treatment of persistent atrial fibrillation? Circ J, 73: 1008-1009, 2009.
5. Kang, L., Zheng, M. Q., Morishima, M., Wang, Y., Kaku, T., and Ono, K. Bepridil up-regulates cardiac Na+ channels as a long-term effect by blunting proteasome signals through inhibition of calmodulin activity. Br J Pharmacol, 157: 404-414, 2009.
6. Yamashita, T., Ogawa, S., Sato, T., Aizawa, Y., Atarashi, H., Fujiki, A., Inoue, H., Ito, M., Katoh, T., Kobayashi, Y., Koretsune, Y., Kumagai, K., Niwano, S., Okazaki, O., Okumura, K., Saku, K., Tanabe, T., and Origasa, H. Dose-response effects of bepridil in patients with persistent atrial fibrillation monitored with transtelephonic electrocardiograms: a multicenter, randomized, placebo-controlled,double-blind study (J-BAF Study). Circ J, 73: 1020-1027, 2009.
7. Watanabe, M., Takata, Y., Fukasawa, S., Sakota, K., Abe, T., Goseki, Y., Setoguchi, Y., Chikamori, T., and Yamashina, A. Two patients with bepridil-induced interstitial pneumonia. Circ J, 73: 1352-1355, 2009.