Bepridil hydrochloride

Catalog #:

IN0051

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IN0052-100mg

USD100.0

Synonyms: Vascor

IUPAC Name:

N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline hydrochloride

Functional Activity:

Bepridil is a calcium channel blocker once used to treat angina. It also blocks Na⁺/Ca²⁺ exchanger (NCX), sodium and K_ATP channels. Anti-arrhythmic and antihypertensive.

Technical Data:

M.Wt: 403.00

Formula: C₂₄H₃₅N₂O.HCl

Solubility: Soluble to 100 mM in DMSO

Purity: >97%

Storage: Dessicate at RT

CAS No.: 74764-40-2

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References for Bepridil hydrochloride :

1. Suzuki, T., Hanaoka, M., Yokoyama, T., Koizumi, T., and Kubo, K. Gradual progression of interstitial pneumonia induced by bepridil. Intern Med, 48: 2033-2035, 2009.

2. Miyazaki, S., Kuwahara, T., Kobori, A., Takahashi, Y., Takei, A., Sato, A., Isobe, M., and Takahashi, A. Pharmacological cardioversion preceding left atrial ablation: bepridil predicts the clinical outcome following ablation in patients with persistent atrial fibrillation. Europace, 11: 1620-1623, 2009.

3. Osaka, T., Yokoyama, E., Kushiyama, Y., Hasebe, H., Kuroda, Y., Suzuki, T., and Kodama, I. Opposing effects of bepridil on ventricular repolarization in humans. Inhomogeneous prolongation of the action potential duration vs flattening of its restitution kinetics. Circ J, 73: 1612-1618, 2009.

4. Hirao, K. Does bepridil create a paradigm shift in the treatment of persistent atrial fibrillation? Circ J, 73: 1008-1009, 2009.

5. Kang, L., Zheng, M. Q., Morishima, M., Wang, Y., Kaku, T., and Ono, K. Bepridil up-regulates cardiac Na+ channels as a long-term effect by blunting proteasome signals through inhibition of calmodulin activity. Br J Pharmacol, 157: 404-414, 2009.

6. Yamashita, T., Ogawa, S., Sato, T., Aizawa, Y., Atarashi, H., Fujiki, A., Inoue, H., Ito, M., Katoh, T., Kobayashi, Y., Koretsune, Y., Kumagai, K., Niwano, S., Okazaki, O., Okumura, K., Saku, K., Tanabe, T., and Origasa, H. Dose-response effects of bepridil in patients with persistent atrial fibrillation monitored with transtelephonic electrocardiograms: a multicenter, randomized, placebo-controlled,double-blind study (J-BAF Study). Circ J, 73: 1020-1027, 2009.

7. Watanabe, M., Takata, Y., Fukasawa, S., Sakota, K., Abe, T., Goseki, Y., Setoguchi, Y., Chikamori, T., and Yamashina, A. Two patients with bepridil-induced interstitial pneumonia. Circ J, 73: 1352-1355, 2009.

Certificate of Analysis/MSDS is available upon request with lot number