2-APB
Catalog #:
IN0051| IN0051-100mg | USD66.0 |
Synonyms: 2-Aminoethoxydiphenyl borate, 2-APB, 2-Aminoethyl diphenyl borate
IUPAC Name:
2-DiphenylboranyloxyethanamineFunctional Activity:
2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors (IC50 = 42 μM) and TRP channels (< 10 μM) [although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations (up to 50 μM)]. In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although there its lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin26 or connexin32.
Technical Data:
M.Wt: 225.1
Formula: C14H16BNO
Solubility: Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity: >97%
Storage: Dessicate at RT
CAS No.: 524-95-8
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References for 2-APB :
1. Hagenston, A. M., Rudnick, N. D., Boone, C. E., and Yeckel, M. F. 2-Aminoethoxydiphenyl-borate (2-APB) increases excitability in pyramidal neurons. Cell Calcium, 45: 310-317, 2009.
2. Schindl, R., Bergsmann, J., Frischauf, I., Derler, I., Fahrner, M., Muik, M., Fritsch, R., Groschner, K., and Romanin, C. 2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size. J Biol Chem, 283: 20261-20267, 2008.
3. Hamaguchi, Y., Matsubara, T., Amano, T., Uetani, T., Asano, H., Iwamoto, T., Furukawa, K., Murohara, T., and Nakayama, S. Na(+)-independent Mg(2+) transport sensitive to 2-aminoethoxydiphenyl borate (2-APB) in vascular smooth muscle cells: involvement of TRPM-like channels. J Cell Mol Med, 12: 962-974, 2008.
4. Peinelt, C., Lis, A., Beck, A., Fleig, A., and Penner, R. 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels. J Physiol, 586: 3061-3073, 2008.
5. Togashi, K., Inada, H., and Tominaga, M. Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br J Pharmacol, 153: 1324-1330, 2008.
6. Juvin, V., Penna, A., Chemin, J., Lin, Y. L., and Rassendren, F. A. Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate. Mol Pharmacol, 72: 1258-1268, 2007.
