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IN0048-1g USD93.0

References for Colchicine:

1. Huzil, J. T., Barakat, K., and Tuszynski, J. A. Electrostatic contributions to colchicine binding within tubulin isotypes. Electromagn Biol Med, 28: 355-364, 2009.

2. Tripathi, A., Durrant, D., Lee, R. M., Baruchello, R., Romagnoli, R., Simoni, D., and Kellogg, G. E. Hydropathic analysis and biological evaluation of stilbene derivatives as colchicine site microtubule inhibitors with anti-leukemic activity. J Enzyme Inhib Med Chem, 24: 1237-1244, 2009.

3. Fellows, M. D. and O'Donovan, M. R. Etoposide, cadmium chloride, benzo[a]pyrene, cyclophosphamide and colchicine tested in the in vitro mammalian cell micronucleus test (MNvit) in the presence and absence of cytokinesis block using L5178Y mouse lymphoma cells and 2-aminoanthracene tested in MNvit in the absence of cytokinesis block using TK6 cells at AstraZeneca UK, in support of OECD draft Test Guideline 487. Mutat Res, 702: 163-170.

4. Dahan, A., Sabit, H., and Amidon, G. L. Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine. Drug Metab Dispos, 37: 2028-2036, 2009.

5. Soulere, L. Toward docking-based virtual screening for discovering antitubulin agents by targeting taxane and colchicine binding sites. ChemMedChem, 4: 161-163, 2009.

Certificate of Analysis/MSDS is available upon request with lot number

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