Tetrandrine
Catalog #:
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IN0047-50mg | USD69.0 |
Synonyms: Tetrandrine
IUPAC Name:
6,6',7,12-tetramethoxy-2,2'-dimethyl-1 beta-berbamanFunctional Activity:
Tetrandrine is a calcium channel blocker. It has anti-inflammatory, immunologic and antiallergenic effects. It inhibits the degranulation of mast cells. It has a "Quinidine like" anti-arrhythmic effect. It has been isolated from Stephania tetandra and other Chinese and Japanese Herbs. It shows anti-cancer effects.Technical Data:
M.Wt: 622.75
Formula: C38H42N2O6
Solubility: Soluble in 100 mM DMSO
Purity: >97%
Storage: Store at room temperature
CAS No.: 518-34-3
Certificate of Analysis/MSDS is available upon request with lot number
Related Products by Target:
Solubility: Soluble in 100 mM DMSO
Purity: >97%
Storage: Store at room temperature
CAS No.: 518-34-3
Certificate of Analysis/MSDS is available upon request with lot number
Related Products by Target:
Storage: Store at room temperature
CAS No.: 518-34-3
Certificate of Analysis/MSDS is available upon request with lot number
Related Products by Target:
Certificate of Analysis/MSDS is available upon request with lot number
Related Products by Target:
References for Tetrandrine:
1. Cho, H. S., Chang, S. H., Chung, Y. S., Shin, J. Y., Park, S. J., Lee, E. S., Hwang, S. K., Kwon, J. T., Tehrani, A. M., Woo, M., Noh, M. S., Hanifah, H., Jin, H., Xu, C. X., and Cho, M. H. Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells. J Vet Sci, 10: 23-28, 2009.
2. Chen, Y., Chen, J. C., and Tseng, S. H. Tetrandrine suppresses tumor growth and angiogenesis of gliomas in rats. Int J Cancer, 124: 2260-2269, 2009.
3. Liu, B., Wang, T., Qian, X., Liu, G., Yu, L., and Ding, Y. Anticancer effect of tetrandrine on primary cancer cells isolated from ascites and pleural fluids. Cancer Lett, 268: 166-175, 2008.
4. Chen, X. L., Ren, K. H., He, H. W., and Shao, R. G. Involvement of PI3K/AKT/GSK3beta pathway in tetrandrine-induced G1 arrest and apoptosis. Cancer Biol Ther, 7: 1073-1078, 2008.
5. Sun, X. C., Cheng, H. Y., Deng, Y. X., Shao, R. G., and Ma, J. Tetrandrine: a potent abrogator of G2 checkpoint function in tumor cells and its mechanism. Biomed Environ Sci, 20: 495-501, 2007.
6. Nomura, M., Yamazaki, R., Takaya, M., Kikuchi, M., Takahashi-Nishioka, T., Akiyama, K., Akiyama, N., Moritani, S., and Kobayashi, S. Inhibition of tetrandrine on epidermal growth factor-induced cell transformation and its signal transduction. Anticancer Res, 27: 3187-3193, 2007.