CFTR(inh)-172
Catalog #:
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Synonyms: CFTR(inh)-172
IUPAC Name:
4-[[4-Oxo-2-thioxo-3-[3-trifluorome thyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acidFunctional Activity:
Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.Technical Data:
M.Wt: 409.4
Formula: C18H10F3NO3S2
Solubility: Soluble in 100 mM DMSO
Purity: >97%
Storage: Store at 4 °C
CAS No.: 307510-92-5
Related Products by Target:
Solubility: Soluble in 100 mM DMSO
Purity: >97%
Storage: Store at 4 °C
CAS No.: 307510-92-5
Related Products by Target:
Storage: Store at 4 °C
CAS No.: 307510-92-5
Related Products by Target:
Related Products by Target:
References for CFTR(inh)-172:
1. Kelly, M., Trudel, S., Brouillard, F., Bouillaud, F., Colas, J., Nguyen-Khoa, T., Ollero, M., Edelman, A., and Fritsch, J. Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition. J Pharmacol Exp Ther, 333: 60-69.
2. Caci, E., Caputo, A., Hinzpeter, A., Arous, N., Fanen, P., Sonawane, N., Verkman, A. S., Ravazzolo, R., Zegarra-Moran, O., and Galietta, L. J. Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis. Biochem J, 413: 135-142, 2008.
3. Yang, B., Sonawane, N. D., Zhao, D., Somlo, S., and Verkman, A. S. Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease. J Am Soc Nephrol, 19: 1300-1310, 2008.